FORECAST

Title

Fractional Flow Reserve Derived from Computed Tomography Coronary Angiography in the Assessment and Management of Stable Chest Pain.

Description

This trial aims to test the hypothesis that FFRCT, used as the default screening tool for patients presenting with recent onset stable chest pain, would be associated with (i) shorter rapid time period between initial consultation and definitive management plan; (ii) better patient experience; (iii) lower overall use of resources.

Objectives

Primary Objective:

• To determine whether, in a population of patients presenting to RACPC, routine FFRCT as a default test is superior, in terms of resource utilisation at 9 months, when compared to routine clinical pathway algorithms recommended by NICE CG95.

Secondary Objectives:

• To compare clinical outcomes between the two groups at 9 months.
• To compare the effect on general wellbeing between the two groups at 9 months.

Trial Design

FORECAST is a randomised controlled trial with a sample size of 1400.

Trial Status

Complete

Population

Adults (aged over 18) with primary symptom of chest pain who are deemed to require a test at initial RACPC assessment and are willing and able to provide written informed consent.

Publications

Randomized comparison of chest pain evaluation with FFRCT or standard care: Factors determining US costs. Curzen et al. Journal of Cardiovascular Computed Tomography, 24 September 2022

Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: The FORECAST randomized trial. Nick Curzen, Zoe Nicholas, Beth Stuart, et al.

Contact details

All trial enquiries should be sent to [email protected]