WISH Publications

We are happy to consider applications to collaborate with the agreement of publication authorships. Following are some recent publications by core staff within the WISH lab or working in association with the WISH lab team and facilities.

Articles

Respiratory

Wilkinson, T. M. A., Aris, E., Bourne, S., Clarke, S. C., Peeters, M., Pascal, T. G., ... Devaster, J-M. (2017). A prospective, observational cohort study of the seasonal dynamics of airway pathogens in the aetiology of exacerbations in COPD. Thorax. DOI: 10.1136/thoraxjnl-2016-209023

Edwards, A., Gao, Y., Allan, R., Ball, D., De Graaf, H., Coelho, T., ... Tebruegge, M. (2017). Corticosteroids and infliximab impair the performance of interferon-γ release assays used for diagnosis of latent tuberculosis. Thorax. DOI: 10.1136/thoraxjnl-2016-209397

Hinks, T., Wallington, J., Williams, A., Djukanovic, R., Staples, K. J., & Wilkinson, T. (2016). Steroid-induced deficiency of mucosal-associated invariant T cells in the COPD lung: implications for NTHi infection. American Journal of Respiratory and Critical Care Medicine, 1-63. DOI: 10.1164/rccm.201601-0002OC

Cancer

Drennan, S., D'Avola, A., Gao, Y., Weigel, C., Chrysostomou, E., Steele, A. J., ... Forconi, F. (2017). IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus . Leukemia, 1-9. DOI: 10.1038/leu.2016.356

Tod, J., Hanley, C., Morgan, M. R., Rucka, M., Mellows, T., Lopez, M-A., ... Thomas, G. (2017). Pro-migratory and TGF-β-activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8-dependent GTPase switch. The Journal of Pathology. DOI: 10.1002/path.4923

Crabb, S. J., Birtle, A. J., Martin, K., Downs, N., Ratcliffe, I., Maishman, T., ... Jones, R. J. (2017). ProCAID: a phase I clinical trial to combine the AKT inhibitor AZD5363 with docetaxel and prednisolone chemotherapy for metastatic castration resistant prostate cancer. Investigational New Drugs, 1-9. DOI: 10.1007/s10637-017-0433-4

Hanley, C. J., Noble, F., Ward, M., Bullock, M., Drifka, C., Mellone, M., ... Thomas, G. J. (2016). A subset of myofibroblastic cancer-associated fibroblasts regulate collagen fiber elongation, which is prognostic in multiple cancers. Oncotarget, 7(5), 6159-6174. DOI: 10.18632/oncotarget.6740

Wood, O., Woo, J., Seumois, G., Savelyeva, N., Mccann, K. J., Singh, D., ... Ottensmeier, C. (2016). Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors. Oncotarget, 1-17. DOI: 10.18632/oncotarget.10788

Chakravarthy, A., Henderson, S., Thirdborough, S. M., Ottensmeier, C. H., Su, X., Lechner, M., ... Fenton, T. R. (2016). Human papillomavirus drives tumor development throughout the head and neck: improved prognosis is associated with an immune response largely restricted to the oropharynx. Journal of Clinical Oncology, 1-12. DOI: 10.1200/JCO.2016.68.2955

Mccann, K. J., Mander, A., Cazaly, A., Chudley, L., Stasakova, J., Thirdborough, S. M., ... Ottensmeier, C. H. (2016). Targeting carcinoembryonic antigen with DNA vaccination: on-target adverse events link with immunological and clinical outcomes. Clinical Cancer Research, 1-33. DOI: 10.1158/1078-0432.CCR-15-2507

Bhome, R., Al Saihati, H., Goh, R., Bullock, M., Primrose, J., Thomas, G., ... Mirnezami, A. (2016). Translational aspects in targeting the stromal tumour microenvironment: from bench to bedside. New Horizons in Translational Medicine, 3(1), 9-21. DOI: 10.1016/j.nhtm.2016.03.001

Noble, F., Mellows, T., McCormick Matthews, L. H., Bateman, A., Harris, S., Underwood, T., ... Ottensmeier, C. H. (2016). Tumour infiltrating lymphocytes correlate with improved survival in patients with oesophageal adenocarcinoma. Cancer Immunology Immunotherapy, 65(6), 651-662. DOI: 10.1007/s00262-016-1826-5

Ottensmeier, C. H., Perry, K. L., Harden, E. L., Stasakova, J., Jenei, V., Fleming, J., ... Thirdborough, S. M. (2016). Upregulated glucose metabolism correlates inversely with CD8+ T cell infiltration and survival in squamous cell carcinoma. Cancer Research, 76(14), 1-40. DOI: 10.1158/0008-5472.CAN-15-3121

Cummin, T., & Johnson, P. (2016). Lymphoma: turning biology into cures. Clinical Medicine, 16(6), 125-129. DOI:10.7861/clinmedicine.16-6-s125DOI: 10.1158/1541-7786.MCR-14-0466

Karydis, I., Ottensmeier, C., Wheater, M., Arriola Aperribay, E., Szlozarek, P., & Chan, P. Y. (2016). Clinical activity and safety of Pembrolizumab in Ipilimumab pre-treated patients with uveal melanoma. Oncoimmunology, 1-23. DOI: 10.1080/2162402X.2016.1143997

Powles, T., Brown, J., Larkin, J., Jones, R., Ralph, C., Hawkins, R., ... Nathan, P. (2016). A randomised, double-blind phase II study evaluating cediranib vs cediranib and saracatinib in patients with relapsed metastatic clear cell renal cancer (COSAK). Annals of Oncology, 27(5), 880-886. DOI: 10.1093/annonc/mdw014

Graça, I., Pereira-Silva, E., Henrique, R., Packham, G., Crabb, S. J., & Jerónimo, C. (2016). Epigenetic modulators as therapeutic targets in prostate cancer. Clinical Epigenetics, 8(98), 1-24. DOI: 10.1186/s13148-016-0264-8

Aguilar-Hernandez, M. M., Blunt, M., Dobson, R., Yeomans, A., Thirdborough, S., Larrayoz, M., ... Steele, A. J. (2016). IL-4 enhances expression and function of surface IgM in CLL cells. Blood, 1-25. DOI: 10.1182/blood-2015-11-682906

Johnson, P., Challis, R., Chowdhury, F., Gao, Y., Harvey, M., Geldart, T., ... Williams, A. (2015). Clinical and Biological Effects of an Agonist Anti-CD40 Antibody: A Cancer Research UK Phase I Study. Clinical Cancer Research, 21(6), 1321-1328. DOI: 10.1158/1078-0432.CCR-14-2355

Cellura, D., Pickard, K., Quaratino, S., Parker, H., Strefford, J. C., Thomas, G. J., ... Peake, N. J. (2015). miR-19-mediated inhibition of transglutaminase-2 leads to enhanced invasion and metastasis in colorectal cancer. Molecular Cancer Research, 13(7), 1095-1105.

Roghanian, A., Teige, I., Mårtensson, L., Cox, K. L., Kovacek, M., Ljungars, A., ... Cragg, M. S. (2015). Antagonistic human FcyRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo. Cancer Cell, 27(4), 473-488. DOI: 10.1016/j.ccell.2015.03.005

Hargreaves, C., Iriyama, C., Rose-Zerilli, M., Nagelkerke, S. Q., Hussain, K., Ganderton, R., ... Strefford, J. (2015). Evaluation of high-throughput genomic assays for the Fc Gamma Receptor Locus . PLoS ONE, 10(11), e0142379-[13pp]. DOI: 10.1371/journal.pone.0142379

Vaughan, A. T., Iriyama, C., Beers, S. A., Chan, C. H. T., Lim, S. H., Williams, E. L., ... Cragg, M. S. (2014). Inhibitory FcyRIIb (CD32b) becomes activated by therapeutic mAb in both cis and trans and drives internalization according to antibody specificity . Blood, 123(5), 669-677. DOI: 10.1182/blood-2013-04-490821

Dean, H. F., Cazaly, A., Hurlock, C., Borras, J., Williams, A. P., Johnson, P. W. M., & Davies, A. J. (2012). Defects in lymphocyte subsets and serological memory persist a median of 10 years after high-dose therapy and autologous progenitor cell rescue for malignant lymphoma. Bone Marrow Transplantation. DOI: 10.1038/bmt.2012.73

Lim, S., Vaughan, A., Ashton-Key, M., Williams, E. L., Dixon, S., Chan, H. T. C., ... Glennie, M. (2011). Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy. Blood, 118(9), 2530-2540. DOI: 10.1182/blood-2011-01-330357

Lim, S. H., Beers, S. A., French, R. R., Johnson, P. W., Glennie, M. J., & Cragg, M. S. (2010). Anti-CD20 monoclonal antibodies: historical and future perspectives. Haematologica, 95(1), 135-143. DOI: 10.3324/haematol.2008.001628

Rare Diseases

Gao, Y., Arkwright, P. D., Darley, R., Cazaly, A., Harrison, R. J., Mant, A., ... Williams, A. (2016). Bone marrow transplantation for MHC class I deficiency corrects T-cell immunity but dissociates natural killer cell repertoire formation from function. Journal of Allergy and Clinical Immunology, 138(6), 1733-1736.e2. DOI: 10.1016/j.jaci.2016.06.029

Ramakrishnan, K., Pengelly, R., Gao, Y., Morgan, M., Patel, S., Davies, G., ... Williams, T. (2016). Precision molecular diagnosis defines specific therapy in combined immunodeficiency with megaloblastic anaemia secondary to MTHFD1 deficiency. The Journal of Allergy and Clinical Immunology: In Practice, 4(6), 1160-1166.e10. DOI: 10.1016/j.jaip.2016.07.014

Rae, W., Ramakrishnan, K., Gao, Y., Ashton-Key, M., Pengelly, R., Patel, S. V., ... Faust, S. (2016). Precision treatment with sirolimus in a case of activated phosphoinositide 3-kinase delta syndrome. Clinical Immunology, 171, 38-40. DOI: 10.1016/j.clim.2016.07.017

Rae, W., Gao, Y., Bunyan, D., Holden, S., Gilmour, K., Patel, S., ... Williams, A. (2015). A novel FOXP3 mutation causing fetal akinesia and recurrent male miscarriages. Clinical Immunology, 161(2), 284-285. DOI: 10.1016/J.CLIM.2015.09.006