Research group

Interdisciplinary Musculoskeletal Health

4 Stained femur cross sections

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

About

With expertise in regenerative medicine, physiology, engineering, orthopaedics, prosthetics and orthotics, rehabilitation and assistive technologies, epidemiology and clinical trial design, we aim to improve lives by delivering improved treatments, increasing the speed to market of musculoskeletal-focused technology and training the next generation of scientists and engineers. 

The population across the globe is living longer, which brings a number of healthcare challenges, especially in musculoskeletal health. The burden of age-related disease and injury is rising rapidly, having a detrimental impact on people’s quality of life and increasing the costs of healthcare provision. Loss of muscle mass and function is the leading reason for loss of independence in later life, and causes impaired mobility, falls, fractures, physical disability, increased insulin resistance and associated co-morbidities, and mortality. The number of hip fractures is expected to rise to 6.3 million by 2050 and the number of diabetic lower limb amputations has now risen to 7,000 per year in the UK and over 70,000 in the USA. 

The University is working to meet these challenges by creating networks of experts working in interdisciplinary musculoskeletal health research to develop new technologies, interventions and practices that will have a positive effect on people’s lives:

  • FortisNet is an interdisciplinary research network of clinical, academic and industrial partners that aims to develop products and services to transform musculoskeletal health. Launched in 2016, we have fostered over 50 new collaborations with other universities from across the UK, the NHS and industry. We have developed courses with national partners to help innovators understand how to bring medical technologies to market, and through investment in interdisciplinary studentships we are working to dissolve discipline boundaries, to train a new generation of life scientists and engineers for the benefit of society.
  • MyAge (Muscle resilience across the life course: from cells to society) is one of eleven UK Ageing Networks, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council. Led by the Institute for Life Sciences, together with partners from Birmingham, Nottingham and Imperial, the network will guide the future of muscle resilience research through roadmap development and interdisciplinary collaboration.

Research highlights

Preventing the transmission of non-communicable disease risk between generations

Research from the Developmental Origins of Health and Disease Centre demonstrates how the diet and lifestyle choices of prospective parents and pregnant mothers can affect the long-term health of their children.

Using nanoclay gel to regrow, repair and replace damaged cells

Southampton researchers have developed an innovative medical clay that can be used to apply regenerative medicine to patients with musculoskeletal conditions.

People, projects and publications

People

Professor Martin Feelisch

Prof of Exp Med & Int Biol

Research interests

  • Role of Nutrition and Exercise in Health & Resilience
  • Origin-of-Life Chemistry and Evolution
  • Stress Signaling & Redox Regulation

Accepting applications from PhD students

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Professor Martin Kunc

Professor in Business Analytics

Research interests

  • Business Analytics
  • Strategic Modelling
  • Scenario planning
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Professor Martin Solan

Professor of Marine Ecology

Research interests

  • Biodiversity ecosystem function bioturbation benthic ecology

Accepting applications from PhD students

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Dr Martin Stolz

Lecturer-Biomedical + Orth. Tribology
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Dr Martin Warner PhD

Associate Professor
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Professor Martyn Hill

Professor of Electromechanical Systems
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Professor Mary Barker PhD, C Psychol

Prof of Psychology & Behavioural Science

Research interests

  • Mary Barker is Professor of Psychology and Behavioural Science. She has a joint appointment in both the Faculty of Medicine and the School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton UK.  Mary runs a programme of work in both the UK and in low-income countries aiming to engage young people in improving their sense of agency, well-being and mental health, to benefit their health in general but their diets and physical activity habits more specifically. Her team’s approach is participatory and combines social activism focused on engaging young people in the climate change and health agenda and testing methods of one-to-one support and digital resources including smartphone games. Much of this work takes place as part of her NIHR Programme Grant for Applied Research EACH-B (Engaging Adolescents in Changing Behaviour). She partners in this activity with the TALENT network of colleagues with interests in adolescent health and well-being based in institutions in low-and-middle-income countries. Her team also ran a five-country, longitudinal qualitative study with young people throughout the pandemic exploring their experience, mental health, well-being and resilience, data from which supported UK local and national government COVID messaging to young people. She is adjunct professor at the University of Agder, Norway, and has honorary appointments at the University of Witwatersrand, South Africa, and University College London.
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Professor Matthew Garner PhD

Prof Psychology &Affective Neuroscience

Research interests

  • Neuropsychological mechanisms and treatment targets in anxiety disorders. 
  • Psychopharmacology/experimental medicine (acute pharmacological challenge).
  • Psychophysiology (e.g. interoception, autonomic markers of emotion processing),

Accepting applications from PhD students

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Professor Matthew Loxham

Professorial Fellow-Research
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Dr Matthew Rose-Zerilli BSc (Hons), PhD

Lecturer in Integrative Cancer Biology

Research interests

  • Cancer prevention
  • Innate immunity
  • Tumour microenvironment

Accepting applications from PhD students

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Related research institutes, centres and groups

Related research institutes, centres and groups

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We welcome new members. To join, or find out more about FortisNet or MyAge, please email the Institute for Life Sciences team.