ACCEPT
A Phase Ib/II combination of acalabrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) for patient Diffuse Large B-cell Lymphoma (DLBCL)
AGILE
Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment.
AlcoChange
Real world implementation of AlcoChange: A smartphone digital therapeutic to improve outcomes from alcohol-related liver disease.
AURORA
Atezolizumab in patients with urinary tract squamous cell carcinoma: a single arm, open label, multicentre, phase II clinical trial.
BL13
A Randomised Phase II Trial Assessing Trimodality Therapy With or Without Adjuvant Durvalumab (MEDI4736) to Treat Patients with Muscle-Invasive Bladder Cancer.
BRITISH
Using cardiovascular MR identified scar as the Benchmark Risk Identification Tool for Implantable cardioverter defibrillators in patients with Non-Ischemic Cardiomyopathy and Severe systolic Heart failure
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CaDeT
Multicentre trial of the clinical and cost effectiveness of a novel urinary catheter design in reducing catheter-associated urinary tract infection compared with the traditional Foley design.
COAT
A blinded, non-inferiority phase III trial of 5 versus 7 days of oral flucloxacillin in primary care patients with lower limb cellulitis
CONFIRM
Checkpoint blockade for inhibition of relapsed mesothelioma: A phase III trial to evaluate the efficacy of nivolumab in relapsed mesothelioma
CONTRACT 2
CONservative TReatment of Appendicitis in Children – a randomised controlled Trial – CONTRACT 2
CRAIN
A phase 1b TiTE-CRM dose escalation clinical trial of ASTX660 in combination with standard radical chemoradiotherapy in cervical cancer.
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Cancer Vaccine Launch Pad (CVLP)
CVLP is a project to establish the feasibility of pathways to enable NHS patients with cancer to access cancer vaccine trials.
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DECIPHER
A Single arm phase II trial of trastuzumab deruxtecan in patients with gastrooesophageal adenocarcinoma cancer who are ctDNA and HER2 positive.
ELECTRA
A double-blinded feasibility study of intraoperative electron beam radiotherapy in patients with locally advanced or locally recurrent rectal cancer.
Elevate
Temozolomide plus nivolumab in MGMT deficient oesophagogastric cancer.
EQUATE
Barriers and facilitators to EQUitable pArticipation and engagement in research using digiTal mEthods:
EXCALIBUR
EXCALIBUR is a Phase III feasibility trial of SFJD in addition to best current practice for the treatment of AECOPD in UK primary care.
HARE-40
Therapeutic HPV vaccine trial +/- anti-CD40 in HPV-driven squamous cell carcinoma
HIPEC-PMP
A single blinded, randomised controlled study to compare HIPEC with low-mitomycin C (MMC) and HIPEC with high-dose mitomycin C in the treatment of pseudomyxoma peritonei (PMP).
iDx Lung
A prospective study investigating autoantibody, protein/nucleic acid, and transcriptomic signatures from individuals receiving lung health checks at mobile scanners in Wessex and Yorkshire
IELSG 32
A randomised Phase II Trial on high-dose Methotrexate and Cytarabine, with or without Thiotepa and Rituximab followed by brain irradiation vs. high-dose chemotherapy patients with primary CNS lymphoma
IELSG 37
A randomized, open-label, two-arm phase III comparative study assessing the role of mediastinal radiotherapy after Rituximab chemotherapy to patients with newly diagnosed Primary Mediastinal Large B-Cell Lymphoma
IELSG 42
A phase II trial assessing sequential Methotrexate-Aracytin-based and R-ICE combinations, followed by high-dose chemotherapy in patients with systemic B-cell lymphoma with central nervous system involvement
MANCAN2
A virtual self-help cognitive behavioural therapy intervention to reduce the impact of hot flush and night sweat symptoms in men with prostate cancer undergoing androgen deprivation therapy.
MaPLe
Molecular Profiling for Lymphoma
Mustang
Investigating the role of Miglustat in the management of a patient with Tangier’s Disease: a single case experiment
mySmartCOPD
Exploring the safety and effects of the mySmartCOPD system for COPD patients.
Neo-POLEM
Investigating the role of Miglustat in the management of a patient with Tangier’s Disease: a single case experiment
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NERO
Niraparib Efficacy in patients with unResectable MesotheliOma: A randomised phase II trial of Niraparib versus active symptom control in patients with previously treated mesothelioma
OCTOPuS
Optimising Cardiac Surgery ouTcOmes in People with diabeteS – Intervention Development Study
OptiMATe
Optimizing MATRix as remission induction in PCNSL: De-escalated induction treatment in newly diagnosed primary CNS lymphoma – a randomized phase III trial.
Orange II Plus
An international multicentre randomised controlled trial comparing open and laparoscopic hemihepatectomy within an enhanced recovery (ERAS) programme
Pola-R-ICE
Polatuzumab vedotin plus rituximab, ifosfamide, carboplatin and etoposide (Pola-R-ICE) versus R-ICE alone in second line treatment of diffuse large B-cell lymphoma (DLBCL)
P+R-ICE
An open-label, multicentre, randomised phase II Pembrolizumab in combination with R-ICE chemotherapy in relapsed/refractory diffuse large B-cell lymphoma.
REMoDL-A
A randomised Phase II Evaluation of Molecular Guided Therapy for Diffuse Large B-Cell Lymphoma with Acalabrutinib.
REMoDL-B
A Randomised Evaluation of Molecular guided therapy for Diffuse Large B-cell Lymphoma with Bortezomib
RiVa
A phase IIa study of Rituximab and Varlilumab in relapsed or refractory B-cell malignancies
SELECTmeso
SynthEtic LEthal Cancer Therapy in mesothelioma (SELECTmeso): a molecularly stratified multi-arm phase II platform trial for patients with relapsed malignant mesothelioma
SupportBack2
Supporting self-management of low back pain with an internet intervention in primary care: A randomised controlled trial of clinical and cost-effectiveness.
TOURIST
Thoracic Umbrella Radiotherapy Study in stage IV NSCLC
UNIVERSAL
Understanding Infection, Viral Exacerbation and Respiratory Symptoms at Admission - Longitudinal (UNIVERSAL) Study
VALUE
Understanding the variation of modern endoscopic ultrasound use in patients with oesophageal cancer (VALUE): a multi-methods study
AfLOAT
Antibiotics For uncomplicated LRTI in Older AdulTs