Research group

Interdisciplinary Musculoskeletal Health

4 Stained femur cross sections

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

About

With expertise in regenerative medicine, physiology, engineering, orthopaedics, prosthetics and orthotics, rehabilitation and assistive technologies, epidemiology and clinical trial design, we aim to improve lives by delivering improved treatments, increasing the speed to market of musculoskeletal-focused technology and training the next generation of scientists and engineers. 

The population across the globe is living longer, which brings a number of healthcare challenges, especially in musculoskeletal health. The burden of age-related disease and injury is rising rapidly, having a detrimental impact on people’s quality of life and increasing the costs of healthcare provision. Loss of muscle mass and function is the leading reason for loss of independence in later life, and causes impaired mobility, falls, fractures, physical disability, increased insulin resistance and associated co-morbidities, and mortality. The number of hip fractures is expected to rise to 6.3 million by 2050 and the number of diabetic lower limb amputations has now risen to 7,000 per year in the UK and over 70,000 in the USA. 

The University is working to meet these challenges by creating networks of experts working in interdisciplinary musculoskeletal health research to develop new technologies, interventions and practices that will have a positive effect on people’s lives:

  • FortisNet is an interdisciplinary research network of clinical, academic and industrial partners that aims to develop products and services to transform musculoskeletal health. Launched in 2016, we have fostered over 50 new collaborations with other universities from across the UK, the NHS and industry. We have developed courses with national partners to help innovators understand how to bring medical technologies to market, and through investment in interdisciplinary studentships we are working to dissolve discipline boundaries, to train a new generation of life scientists and engineers for the benefit of society.
  • MyAge (Muscle resilience across the life course: from cells to society) is one of eleven UK Ageing Networks, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council. Led by the Institute for Life Sciences, together with partners from Birmingham, Nottingham and Imperial, the network will guide the future of muscle resilience research through roadmap development and interdisciplinary collaboration.

Research highlights

Preventing the transmission of non-communicable disease risk between generations

Research from the Developmental Origins of Health and Disease Centre demonstrates how the diet and lifestyle choices of prospective parents and pregnant mothers can affect the long-term health of their children.

Using nanoclay gel to regrow, repair and replace damaged cells

Southampton researchers have developed an innovative medical clay that can be used to apply regenerative medicine to patients with musculoskeletal conditions.

People, projects and publications

People

Professor Stuart Clarke PhD FRCPath FFPH

Professor of M'biology and Public Health

Accepting applications from PhD students

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Professor Sue Latter

Professor of Health Services Research

Research interests

  • Medicines management
  • Prescribing
  • End-of-life medicines management
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Professor Sumeet Mahajan MSc, MTech, PhD, FHEA, FRSC

Prof of Molecular BioPhotonics & Imaging

Research interests

  • New chemical biology methods based on Raman spectroscopy and label-free imaging
  • Methodology and device development for commercialisation and clinical translation
  • Neuro-diagnostics and early detection of dementia and neurodegenerative diseases

Accepting applications from PhD students

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Dr Sylvia Pender

Associate Professor
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Dr Tess Maguire

Principal Teaching Fellow
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Professor Thanassis Tiropanis

Professor

Research interests

  • Decentralised information systems and infrastructures
  • Data (and Web) observatories
  • Bias in datasets and incassible algorithms

Accepting applications from PhD students

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Professor Thomas Blumensath

Professor

Research interests

  • I develop and study advanced algorithms that can solve challenging inverse problems by efficiently exploiting complex prior information. Using techniques from mathematics, statistics and machine learning, my work concentrates primarily on problems in x-ray tomographic image reconstruction and modelling.
  • I work closely with state-of-the-art imaging facilities (µ-VIS, the National Research Facility in Lab-based XCT, the UK’s synchrotron facility at the Diamond Light Source, and ISIS neutron imaging beamline) to find practical solutions to a range of important scientific problems from plant science to manufacturing.
  • My research interests cover areas such as: Theoretical and computational methods for Signal and Image Processing (Machine Learning, Compressed Sensing, Statistical Signal and Image Processing, Quantum Computing, Inverse Problems, Optimisation, X-ray Tomographic Imaging); Advanced tomographic imaging strategies: (limited angle tomography and laminography, Spectral X-ray imaging, Stereo and extreme limited view tomography); Efficient computational methods for tomographic reconstruction, including GPU acceleration, distributed computation and advanced optimisation strategies, Constrained optimisation for ill-conditioned and underdetermined   tomographic inverse problems, Applications of X-ray tomography to the inspection of manufactured components, Multimodal tomographic imaging

Accepting applications from PhD students

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Dr Thomas Richardson B.A.(Hons), D.Clin.Psych

Assoc Professor in Clinical Psychology

Research interests

  • Relationship between Financial Difficulties such as Debt and Impulsive Spending and Mental Health
  • Psychological understanding and treatment of Bipolar Disorder
  • Cannabis Use and Psychosis

Accepting applications from PhD students

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Professor Tim Fenton

Professor

Accepting applications from PhD students

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Professor Tim Minshull

Professor in Ocean & Earth Science

Research interests

  • Continental breakup and the onset of seafloor spreading
  • Methane hydrate beneath the seafloor and its role in the Earth system
  • Exploration geophysics: seismic and electromagnetic imaging

Accepting applications from PhD students

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Related research institutes, centres and groups

Related research institutes, centres and groups

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We welcome new members. To join, or find out more about FortisNet or MyAge, please email the Institute for Life Sciences team.