Research group

Interdisciplinary Musculoskeletal Health

4 Stained femur cross sections

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

About

With expertise in regenerative medicine, physiology, engineering, orthopaedics, prosthetics and orthotics, rehabilitation and assistive technologies, epidemiology and clinical trial design, we aim to improve lives by delivering improved treatments, increasing the speed to market of musculoskeletal-focused technology and training the next generation of scientists and engineers. 

The population across the globe is living longer, which brings a number of healthcare challenges, especially in musculoskeletal health. The burden of age-related disease and injury is rising rapidly, having a detrimental impact on people’s quality of life and increasing the costs of healthcare provision. Loss of muscle mass and function is the leading reason for loss of independence in later life, and causes impaired mobility, falls, fractures, physical disability, increased insulin resistance and associated co-morbidities, and mortality. The number of hip fractures is expected to rise to 6.3 million by 2050 and the number of diabetic lower limb amputations has now risen to 7,000 per year in the UK and over 70,000 in the USA. 

The University is working to meet these challenges by creating networks of experts working in interdisciplinary musculoskeletal health research to develop new technologies, interventions and practices that will have a positive effect on people’s lives:

  • FortisNet is an interdisciplinary research network of clinical, academic and industrial partners that aims to develop products and services to transform musculoskeletal health. Launched in 2016, we have fostered over 50 new collaborations with other universities from across the UK, the NHS and industry. We have developed courses with national partners to help innovators understand how to bring medical technologies to market, and through investment in interdisciplinary studentships we are working to dissolve discipline boundaries, to train a new generation of life scientists and engineers for the benefit of society.
  • MyAge (Muscle resilience across the life course: from cells to society) is one of eleven UK Ageing Networks, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council. Led by the Institute for Life Sciences, together with partners from Birmingham, Nottingham and Imperial, the network will guide the future of muscle resilience research through roadmap development and interdisciplinary collaboration.

Research highlights

Preventing the transmission of non-communicable disease risk between generations

Research from the Developmental Origins of Health and Disease Centre demonstrates how the diet and lifestyle choices of prospective parents and pregnant mothers can affect the long-term health of their children.

Using nanoclay gel to regrow, repair and replace damaged cells

Southampton researchers have developed an innovative medical clay that can be used to apply regenerative medicine to patients with musculoskeletal conditions.

People, projects and publications

People

Professor Simon Coles

Professor of Structural Chemistry

Research interests

  • The work we do is highly collaborative and multidisciplinary and can broadly be split into three overlapping themes:
  • 1) National Crystallography Service (NCS, www.ncs.ac.uk) & Physical Sciences Data-science Service (PSDS, www.psds.ac.uk) These national centres provide centralised facilities for UK researchers at a level that is beyond that achievable in any single institution. The NCS provides data collection and crystal structure analysis for the UK chemistry community. It also performs projects based on more advanced techniques, involving a dedicated team of experts employing cutting edge techniques and the use of very high-powered laboratory diffractometers or the UK synchrotron, Diamond. The PSDS provides national-level access to databases and is building infrastructure on top of these to drive and support data-driven approaches to scientific discovery.
  • 2) Structural Chemistry We have an interest in determining the mechanisms of solid-state reactions and transformations and use a variety of diffraction and physical characterisation methods for this. Other work focuses on discovering and investigating structure-property relationships, the determination of charge densities and their properties and 'value-added' quantum mechanical calculations to compute properties from crystal structures. We also collaborate with other disciplines in a number of areas such as macromolecular crystallography (Biology), crystal growth (biology) and CT imaging (Engineering).

Accepting applications from PhD students

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Professor Simon Cox

Head of Department

Research interests

  • My research focusses on computational tools, technologies and platforms and how they enable interdisciplinary problems to be solved in engineering and science.His team in the Computational Engineering and Design Group is applying and developing high performance and cloud computing in a variety of collaborative interdisciplinary computational science and engineering projects. These include:
  • High Performance and novel Computing SystemsCloud Computing and commercial distributed computing - which led to a spin out companyApplied computational algorithms Computational electromagnetics– which led to the formation of a spin-off company.New algorithms such as meshless methods and fast solvers.Data Management Simon is also Director of the Microsoft Institute for High Performance computing where he demonstrates why, where and how current and future Microsoft tools and technologies can be exploited to enable engineering and scientific research to deliver faster, cheaper and better results.
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Dr Sofia Michopoulou PhD

Accepting applications from PhD students

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Professor Sonia Zakrzewski

Prof of Bioarchaeology & BioAnthropology

Research interests

  • bioarchaeology and palaeopathology
  • disAbility, impairment, injury and disease
  • race, migration and mobility

Accepting applications from PhD students

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Dr Srinandan Dasmahapatra

Associate Professor
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Professor Stefan Bleeck

Prof of Hearing Science and Technology

Research interests

  • The aim of my work is to understand how we hear sound and to use this knowledge to create bio-inspired solutions to enhance speech communication.
  • I have continuously worked on various aspects of hearing research and technology and have been principal investigator on various research grants (EU, EPSRCS, etc) with a value of more than £2M. I am team leader with an internationally recognised research programme to develop devices that help normal hearing and hearing-impaired people to communicate better in noise. Methodologies include brainstem physiology, neuronal simulations, deep learing, psychophysics, pupil tracking and other physiological measurements. 

Accepting applications from PhD students

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Dr Stephan Onggo PhD, SFHEA

Professor of Business Analytics

Research interests

  • Simulation Modelling Methodology
  • Behavioural Modelling using Simulation
  • Simulation for real-time decision making (digital twin)

Accepting applications from PhD students

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Professor Stephen Beers

Professor of Immunology & Immunotherapy

Accepting applications from PhD students

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Professor Steve Darby

Associate Dean Research

Research interests

  • River and coastal flooding - relationships between geomorphology and flooding in rivers and deltas
  • Biogeomorphology - interactions between river processes and life
  • River bank erosion processes

Accepting applications from PhD students

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Dr Steven Glautier

Associate Professor

Accepting applications from PhD students

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Related research institutes, centres and groups

Related research institutes, centres and groups

Connect with us

We welcome new members. To join, or find out more about FortisNet or MyAge, please email the Institute for Life Sciences team.