Research group

Interdisciplinary Musculoskeletal Health

4 Stained femur cross sections

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

About

With expertise in regenerative medicine, physiology, engineering, orthopaedics, prosthetics and orthotics, rehabilitation and assistive technologies, epidemiology and clinical trial design, we aim to improve lives by delivering improved treatments, increasing the speed to market of musculoskeletal-focused technology and training the next generation of scientists and engineers. 

The population across the globe is living longer, which brings a number of healthcare challenges, especially in musculoskeletal health. The burden of age-related disease and injury is rising rapidly, having a detrimental impact on people’s quality of life and increasing the costs of healthcare provision. Loss of muscle mass and function is the leading reason for loss of independence in later life, and causes impaired mobility, falls, fractures, physical disability, increased insulin resistance and associated co-morbidities, and mortality. The number of hip fractures is expected to rise to 6.3 million by 2050 and the number of diabetic lower limb amputations has now risen to 7,000 per year in the UK and over 70,000 in the USA. 

The University is working to meet these challenges by creating networks of experts working in interdisciplinary musculoskeletal health research to develop new technologies, interventions and practices that will have a positive effect on people’s lives:

  • FortisNet is an interdisciplinary research network of clinical, academic and industrial partners that aims to develop products and services to transform musculoskeletal health. Launched in 2016, we have fostered over 50 new collaborations with other universities from across the UK, the NHS and industry. We have developed courses with national partners to help innovators understand how to bring medical technologies to market, and through investment in interdisciplinary studentships we are working to dissolve discipline boundaries, to train a new generation of life scientists and engineers for the benefit of society.
  • MyAge (Muscle resilience across the life course: from cells to society) is one of eleven UK Ageing Networks, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council. Led by the Institute for Life Sciences, together with partners from Birmingham, Nottingham and Imperial, the network will guide the future of muscle resilience research through roadmap development and interdisciplinary collaboration.

Research highlights

Preventing the transmission of non-communicable disease risk between generations

Research from the Developmental Origins of Health and Disease Centre demonstrates how the diet and lifestyle choices of prospective parents and pregnant mothers can affect the long-term health of their children.

Using nanoclay gel to regrow, repair and replace damaged cells

Southampton researchers have developed an innovative medical clay that can be used to apply regenerative medicine to patients with musculoskeletal conditions.

People, projects and publications

People

Dr Salah Elias

Associate Professor

Accepting applications from PhD students

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Dr Salah Mansour PhD

Associate Professor

Research interests

  • Unconventioanl T cells in health and disease 
  • CD1 group 1 restricted T cell immunity  
  • Structural and molecular mechainsms of CD1 lipid antigen presentation 

Accepting applications from PhD students

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Professor Salim Khakoo

Professor of Hepatology
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Professor Sally Brailsford

Professor of Management Science

Research interests

  • Healthcare modelling
  • Hybrid simulation
  • Behavioural Operational Research
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Professor Sally Ward

Prof of Mol Imnlgy & Dir of Trtl Imnlgy
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Professor Sam Chamberlain MB/BChir, PhD, MRCPsych

Professor of Psychiatry

Research interests

  • Clinical conditions of interest include Impulsive/Compulsive Disorders; such as but not limited to Gambling disorder, Trichotillomania (hair pulling disorder), Skin picking (also known as excoriation) disorder, Compulsive Stealing, Compulsive Sexual Behaviour Disorder, Attention Deficit Hyperactivity Disorder (ADHD)
  • My work also explores mental health and well-being of university students.
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Dr Sam Thompson

Associate Professor

Research interests

  • Chemical Biology
  • Organic Synthesis
  • Medicinal Chemistry

Accepting applications from PhD students

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Professor Samuele Cortese M.D., Ph.D.

NIHR Research Professor

Research interests

  • Professor Cortese’s main research interests are around neurodevelopmental disorders, with a focus on ADHD, and sleep disorders. In his research, he uses advanced evidence synthesis methods, large datasets and RCTs to inform decision-making in clinical practice.
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Dr Sandra Wilks

Associate Professor

Research interests

  • Applied biofilm research
  • Medical devices
  • Infection prevention

Accepting applications from PhD students

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Dr Sandrine Willaime-Morawek

Associate Professor

Research interests

  • How brain development and function are affected by external factors such as maternal diet
  • In vitro stem cells modelling of neurodevelopmental and neurodegenerative diseases' molecular and cellular pathology

Accepting applications from PhD students

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Related research institutes, centres and groups

Related research institutes, centres and groups

Connect with us

We welcome new members. To join, or find out more about FortisNet or MyAge, please email the Institute for Life Sciences team.