Research project

paraQchip - Parahydrogen-Induced Hyperpolarisation On A Chip For Microfluidic Perfusion Culture

Research groups:

Organic Chemistry, Synthesis, Catalysis
Lead researchers:

Professor Marcel Utz
Other researchers:

Professor Richard Whitby,

Professor Malcolm Levitt,

Professor Ilya Kuprov
Research funder:

EPSRC
Status:

Active

Staff

Lead researchers

Research interests

Integration of microfluidic lab-on-a-chip technology with NMR spectroscopy and imaging;
Behaviour of complex materials.

Connect with Marcel

Email: [email protected]

Other researchers

Research interests

Synthesis, properties and application of atomic and molecular endofullerenes.
The use of flow chemistry for the rapid acquisition of mechanistic and process information.
The synthesis of polyaromatic molecules for optoelectronic applications.

Connect with Richard

Email: [email protected]

Research interests

Magnetic Resonance
Endofullerenes

Connect with Malcolm

Email: [email protected]

Professor Ilya Kuprov FRSC

Professor of Physics

Connect with Ilya

Email: [email protected]

Collaborating research institutes, centres and groups

Magnetic Resonance

Our main focus is finding ways to extend the timescale over which magnetic resonance can be made.

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Robust parahydrogen-induced polarization at high concentrations

Laurynas Dagys, Martin C. Korzeczek, Anna J. Parker , James Eills, John W. Blanchard, Christian Bengs, Malcolm H. Levitt, Stephan Knecht, Ilai Schwartz & Martin B. Plenio, 2024, Science Advances, 10(30)

DOI: 10.1126/sciadv.ado0373

Type: article

Efficient parahydrogen-induced ¹³C hyperpolarization on a microfluidic device

Sylwia J. Barker, Laurynas Dagys, Malcolm H. Levitt & Marcel Utz, 2024, Journal of the American Chemical Society, 146(27), 18379

DOI: 10.1021/jacs.4c03271

Type: article

Quantitative analysis of 2D EXSY NMR spectra of strongly coupled spin systems in transmembrane exchange

Dmitry Shishmarev, Clement Q. Fontenelle, Bruno Linclau, Ilya Kuprov & Philip W. Kuchel, 2023, ChemBioChem, e202300597

DOI: 10.1002/cbic.202300597

Type: article

Simulation and design of shaped pulses beyond the piecewise-constant approximation

Uluk Rasulov, Anupama Acharya, Marina Carravetta, Guinevere Mathies & Ilya Kuprov, 2023, Journal of Magnetic Resonance, 353