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Research project

CCP4: Advanced integrated approaches to macromolecular structure determination

Staff

Lead researchers

Professor Ivo Tews

Professor

Research interests

  • Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit
  • Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections
  • Cancer immunology: together with Cancer Immunology at Southampton we use a structure based apporach in developing novel cancer therapie
Connect with Ivo

Email: [email protected]

Collaborating research institutes, centres and groups

Research outputs

CCP4 Cloud for structure determination and project management in macromolecular crystallography
Eugene Krissinel, Andrey A Lebedev, Ville Uski, Charles B Ballard, Ronan M Keegan, Oleg Kovalevskiy, Robert A Nicholls, Navraj S Pannu, Pavol Skubák, John Berrisford, Maria Fando, Bernhard Lohkamp, Marcin Wojdyr, Adam J Simpkin, Jens M H Thomas, Christopher Oliver, Clemens Vonrhein, Grzegorz Chojnowski, Arnaud Basle, Andrew Purkiss, Michail N Isupov, Stuart McNicholas, Edward Lowe, Josep Triviño, Kevin Cowtan, Jon Agirre, Daniel J Rigden, Isabel Uson, Victor Lamzin, Ivo Tews, Gerard Bricogne, Andrew G W Leslie & David G Brown, 2022, Acta Crystallographica Section D: Structural Biology, 78(Pt 9), 1079-1089
DOI: 10.1107/S2059798322007987
Type: article
Complementarity of neutron, XFEL and synchrotron crystallography for defining the structures of metalloenzymes at room temperature
Tadeo Moreno-Chicano, Leiah M. Carey, Danny Axford, John H. Beale, R. Bruce Doak, Helen M.E. Duyvesteyn, Ali Ebrahim, Robert W. Henning, Diana C.F. Monteiro, Dean A. Myles, Shigeki Owada, Darren A. Sherrell, Megan L. Straw, Vukica Šrajjer, Hiroshi Sugimoto, Kensuke Tono, Takehiko Tosha, Ivo Tews, Martin Trebbin, Richard W. Strange, Kelvin L. Weiss, Jonathan A.R. Worrall, Flora Meilleur, Robin L. Owen, Reza A. Ghiladi & Michael A. Hough, 2022, IUCrJ, 9(Part 5), 610-624
DOI: 10.1107/S2052252522006418
Type: article
Fixed target serial data collection at Diamond Light Source
Sam Horrell, Danny Axford, Nicholas E. Devenish, Ali Ebrahim, Michael A. Hough, Darren A. Sherrell, Selina L.S. Storm, Ivo Tews, Jonathan A.R. Worrall & Robin L. Owen, 2021, JoVE Journal, 2021(168), 1
DOI: 10.3791/62200
Type: article
Serial femtosecond zero dose crystallography captures a water‐free distal heme site in a dye‐decolorising peroxidase to reveal a catalytic role for an arginine in FeIV=O Formation
Marina Lučić, Dimitri A. Svistunenko , Michael T. Wilson, Amanda K. Chaplin, Bradley Davy, Ali Ebrahim, Danny Axford, Takehiko Tosha, Hiroshi Sugimoto, Shigeki Owada, Florian S. N Dworkowski, Ivo Tews, Robin L. Owen, Michael A. Hough & Jonathan A. R. Worrall, 2020, Angewandte Chemie International Edition, 59(48), 21656–21662
DOI: 10.1002/anie.202008622
Type: article
Measuring energy-dependent photoelectron escape in microcrystals
Selina L S Storm, Adam D Crawshaw, Nicholas E Devenish, Rachel Bolton, David R Hall, Ivo Tews & Gwyndaf Evans, 2020, IUCrJ, 7(Part 1), 129-135
DOI: 10.1107/S2052252519016178
Type: article