Regulation of Gene Expression

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

• Illustrate methods to identify key regulatory elements within a eukaryotic promoter
• Explain the structure, formation and function of microRNAs
• Explain the mechanism by which transcription is initiated in eukaryotic cells
• Explain how transcriptional control is achieved through alterations in chromatin structure and methylation
• Outline the mechanisms and factors that control the process of translation.
• Outline the mechanisms by which post-transcriptional control is achieved.

This module covers the structure and expression of genetic material in eukaryotic cells. Regulation of eukaryotic gene expression will be discussed. Selected examples where gene expression has been disrupted will also be covered; this will include the study of transcription factors as oncogenes and tumour suppressor genes. . In subsequent lectures the role of microRNAs in gene regulation and disease will be discussed, together with the factors and mechanisms that control the process of translation.

This course comprises 20 lectures with 4 feedback/revision seminars. For each section of the course the student is given a comprehensive reading list of recent research and review papers. Examination is by a 2 hour written examination.

Summative

This is how we’ll formally assess what you have learned in this module.

Referral

This is how we’ll assess you if you don’t meet the criteria to pass this module.