Cancer Chromosome Biology

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

• Explain the mechanisms of tumour heterogeneity and the relationship to cancer stem cells.
• Describe methods to probe the genome to detect cancer mutations.
• Explain cancer genetics and how somatic mutations drive disease.
• Describe the process of epithelial-mesenchymal transformation and the mechanisms of tumour metastasis.
• Describe how dysregulation of basic cellular signalling pathways contributes to the development of cancer.
• Describe how tumour cells are recognised and targeted by the immune system.
• Explain how tumour-stroma interactions influence cancer progression.
• Describe the processes that control the association and disassociation of chromosomes during cell division.

• Carcinogenesis
• Genetic causes of cancer
• Cancer genomics
• The control of chromosome segregation
• Tumour and immune cell interactions
• The impacts of dysregulated cancer cell signalling
• Epithelial-mesenchymal transformation
• Tumour metastasis and invasion

The module is delivered principally via lectures, supported by informal discussions with lecturers and independent study of recommended reading material.

Summative

This is how we’ll formally assess what you have learned in this module.

Referral

This is how we’ll assess you if you don’t meet the criteria to pass this module.