NMR Spectroscopy: Theory and Application

Learning Outcomes

Learning Outcomes

Having successfully completed this module you will be able to:

• Recognise further applications for NMR spectroscopy in probing supramolecular interactions, understanding the thermodynamics of fluxional processes in solution and following reaction kinetics
• Recognise the steps involved in acquiring NMR spectroscopic data: from sample preparation to setting appropriate acquisition parameters
• Critically evaluate the quality and reliability of your acquired data
• Interpret and assign NMR spectroscopic data as a tool for structural elucidation

1. Liquid state NMR spectroscopy

• Fundamentals of NMR spectroscopy
• Nuclear spin (I = ½, I > ½ nuclei), pulsed RF, relaxation issues: implications for acquisition of data
• Chemical shift, integration, spin coupling – interpretation of 1D NMR data
• Multinuclear NMR (p-block, transition metals)
• Advanced NMR experiments
• 2D NMR (homonuclear and heteronuclear)
• NOE spectroscopy
• VT NMR and fluxionality (both organic and broadband samples)
• Applications of liquid state NMR spectroscopy
• Structural elucidation
• Stereochemistry: determination and assignment
• Binding studies
• Kinetics
• Practical techniques
• Sample preparation
• Sample submission and data acquisition
• Processing data
• Reporting data in literature/reports

2. Advanced applications in solid state and biological NMR spectroscopy

Teaching Methods

• Lectures (two per week: a mixture of plenary lectures and small-group problem solving workshops
• Practical workshops (spaced evenly through the semester, involving interaction with the instrumentation and data interpretation in small groups)
• Directed reading
• Bb online support

Learning Methods

Independent study, student motivated peer-group study, student driven tutor support.

Summative

This is how we’ll formally assess what you have learned in this module.

Referral

This is how we’ll assess you if you don’t meet the criteria to pass this module.