About
Dr V V G Krishna Inavalli is currently the Head of Microscopy Group at the Centre for Cancer Immunology, University of Southampton. He has 15 years of experience in optics and more than 8 years of experience working in an interdisciplinary environment. He has developed various light microscopy techniques ranging from diffraction-limited to super-resolution microscopy techniques to probe cellular biology. Dr. Inavalli's developments aided in the understanding of morpho-molecular interactions of Neuronal Synapses, as well as the exploration of the Brain's extracellular space. He is currently developing cutting-edge technology to investigate antibody based cancer therapeutics.
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Biography
Dr. Inavalli, recived PhD in Physics from the University of Hyderabad, India where he developed a new method to generate structured light beams and studied its applications. During his first postdoctoral position at the University of Illinois at Urbana Champaign (UIUC), USA, he developed novel microscopy techniques to image biological tissues and worked on complex wavefront shaping techniques to image deep in the tissue. During his second postdoctoral position at the Nagerl and Sibarita labs at Interdisciplinary Institute for Neurosciences (IINS), Bordeaux, France, he developed and applied cutting-edge super-resolution microscopy techniques in cellular neuroscience.
Dr. Inavalli, developed a correlative super-resolution microscope technic by combining STED with SMLM in a single microscope to uncover neuronal synapses' morphological and molecular organization and their dynamics (Inavalli et.al, Nature Methods 2019). He contributed to the development of a new super-resolution microscopy technique called SUper-resolution SHadow Imaging (SUSHI) to probe brain extracellular space (Tonnesen et. al., Cell 2018). He also developed an adaptive optics 3D STED microscope using spatial light modulators to investigate the interaction between different synaptic partners in combination with SUSHI labelling (Misa et.al Glia 2021, Nature communication 2020).
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