Research project

Structural plasticity in antigen selection - Werner - BBSRC

Lead researchers:

Dr Joern Werner
Research funder:

Biotechnology & Biological Sciences Research Council
Status:

Not active

Staff

Lead researchers

Dr Joern Werner

Reader in Structural Biology

Connect with Joern

Email: [email protected]

Research outputs

Kinetics of abacavir-induced remodelling of the major histocompatibility complex class I peptide repertoire

Patricia Illing, Andy van Hateren, Rachel Darley, Nathan Croft, Nicole Mifsud, Samuel King, Lyudmila Kostenko, Mandvi Bharadwaj, James McCluskey, Timothy Elliott & Anthony Purcell, 2021, Frontiers in Immunology, 12

DOI: 10.3389/fimmu.2021.672737

Type: article

The partial dissociation of MHC class I bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1: ERAP1 trimming of MHC I-bound peptides

Athanasios Papakyriakou, Emma Reeves, Mary Beton, Halina Mikolajek, Leon Douglas, Grace Cooper, Timothy Elliott, Jorn M. Werner & Edward James, 2018, The Journal of Biological Chemistry, 293(20), 7538-7548

DOI: 10.1074/jbc.RA117.000313

Type: article

Protein plasticity and peptide editing in the MHC I antigen processing pathway

Tim Elliott & Andrew Van Hateren, 2018, Biochemistry, 57(9), 1423–1425

DOI: 10.1021/acs.biochem.7b01307

Type: review

Direct evidence for conformational dynamics in major histocompatibility complex class I molecules

Andy van Hateren, Malcolm Anderson, Alistair Bailey, Jörn M Werner, Paul Skipp & Tim Elliott, 2017, Journal of Biological Chemistry, 292(49), 20255-20269

DOI: 10.1074/jbc.M117.809624

Type: article

Plasticity of empty major histocompatibility complex class I molecules determines peptide-selector function.

Andy van Hateren, Alistair Bailey, Jörn M. Werner & Tim Elliott, 2015, Molecular Immunology, 68(2), 98-101

DOI: 10.1016/j.molimm.2015.03.010

Type: article