About
The Genomic Informatic group, led by Dr Tapper, specialises in identifying novel germline and somatic variants which influence the risk of developing disease and clinical outcomes and how this knowledge can be translated into improved diagnosis, risk prediction and personalised treatment. The group uses a wide range of bioinformatic and statistical techniques to analyse large-scale genetic datasets including next generation sequencing (NGS), genome-wide association studies (GWAS), polygenic risk scores (PRS), Mendelian randomisation, network analysis, data integration and machine learning.
Research
Research groups
Current research
- Long term follow-up of the POSH cohort to determine disease risks for distant, locoregional and new primary disease in young-onset breast cancer patients with known BRCA1/2 mutation status
- Genome-wide association study of outcome after aneurysmal subarachnoid haemorrhage
- Developing a polygenic risk score for pancreatic cancer
- Utilising multiomic data to understand therapy resistance in paediatric rhabdomyosarcomas
- Utilising patient omic information to identify target mechanisms of resistance in sarcomas
- Genomics of food allergy and food allergen sensitisation
Research projects
Active projects
Researchers:
Completed projects
Sponsor: Breast Cancer Now
Researchers:
Sponsor: Blood Cancer UK
Researchers:
Sponsor: Sarcoma UK
Researchers:
Sponsor: Breast Cancer Research Trust
Researchers:
Sponsor: Blood Cancer UK
Sponsor: Sarcoma UK
Sponsor: Breast Cancer Now
Publications
128 publications
Page 1 of 13
Eleanor O'Brien, Carmen Tse, Ian Tracy, Ian Reddin, Joanna Selfe, Jane Gibson, William Tapper, Reuben J. Pengelly, Jinhui Gao, Ewa Aladowicz, Gemma Petts, Khin Thway, Sergey Popov, Anna Kelsey, Timothy J. Underwood, Janet Shipley & Zoë S. Walters,
2023, Clinical Epigenetics, 15(1)
Type: article
Maria Zanti, Denise G. O'Mahony, Michael T. Parsons, Hongyan Li, Joe Dennis, Kristiina Aittomäkkiki, Irene L. Andrulis, Hoda Anton-Culver, Kristan J. Aronson, Annelie Augustinsson, Heiko Becher, Stig E. Bojesen, Manjeet K. Bolla, Hermann Brenner, Melissa A. Brown, Saundra S. Buys, Federico Canzian, Sandrine M. Caputo, Jose E. Castelao, Jenny Chang-Claude, Kamila Czene, Mary B. Daly, Arcangela De Nicolo, Peter Devilee, Thilo Dörk, Alison M. Dunning, Miriam Dwek, Diana M. Eccles, Christoph Engel, D. Gareth Evans, Peter A. Fasching, Manuela Gago-Dominguez, Montserrat García-Closas, José A. García-Sáenz, Aleksandra Gentry-Maharaj, Willemina R.R. Geurts-Giele, Graham G. Giles, Gord Glendon, Mark S. Goldberg, Encarna B. Gómez Garcia, Melanie Göendert, Pascal Guénel, Eric Hahnen, Christopher A. Haiman, Per Hall, Ute Hamann, Elaine F. Harkness, Anthony Howell, William J. Tapper & Jack A. Taylor,
2023, Human Mutation, 2023
DOI: 10.1155/2023/9961341
Type: article
Rebecca L. McCarthy, Ellen Copson, William Tapper, Helen Bolton, Alex H. Mirnezami, J. Robert O'Neill, Nimesh N. Patel, Marc Tischkowitz & Ramsey I. Cutress,
2023, British Journal of Cancer, 129(3), 383-392
Type: review
Ahmed A. Z. Dawoud, William J. Tapper & Nicholas C. P. Cross,
2023, Science Advances
Type: article
Luz Yurany Moreno Rueda, Dean Bryant, William J Tapper, Nicola J. Weston-Bell, David C. Wedge, Naser Ansari-Pour & Surinder S. Sahota,
2023, Leukemia, 37(4), 929-933
Type: article
Chiea Chuen Khor, Stefan Winter, Natalia Sutiman, Thomas E Mürdter, Sylvia Chen, Joanne Siok Liu Lim, Zheng Li, Jingmei Li, Kar Seng Sim, Boian Ganchev, Diana Eccles, Bryony Eccles, William Tapper, Nathalie K Zgheib, Arafat Tfayli, Raymond Chee Hui Ng, Yoon Sim Yap, Elaine Lim, Mabel Wong, Nan Soon Wong, Peter Cher Siang Ang, Rebecca Dent, Roman Tremmel, Kathrin Klein, Elke Schaeffeler, Yitian Zhou, Volker M Lauschke, Michel Eichelbaum, Matthias Schwab, Hiltrud B Brauch, Balram Chowbay & Werner Schroth,
2023, Clinical Pharmacology and Therapeutics, 113(3), 712-723
DOI: 10.1002/cpt.2846
Type: article
Ben Gaastra, John Zhang, Will Tapper, Diederik Bulters & Ian Galea,
2023, Translational Stroke Research
Type: article
Stefanie H Mueller, Alvina G Lai, Maria Valkovskaya, Kyriaki Michailidou, Manjeet K Bolla, Qin Wang, Joe Dennis, Michael Lush, Zomoruda Abu-Ful, Thomas U Ahearn, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Kristan J Aronson, Annelie Augustinsson, Thais Baert, Laura E Beane Freeman, Matthias W Beckmann, Sabine Behrens, Javier Benitez, Marina Bermisheva, Carl Blomqvist, Natalia V Bogdanova, Stig E Bojesen, Bernardo Bonanni, Hermann Brenner, Sara Y Brucker, Saundra S Buys, Jose E Castelao, Tsun L Chan, Jenny Chang-Claude, Stephen J Chanock, Ji-Yeob Choi, Wendy K Chung, Sarah V Colonna, Sten Cornelissen, Fergus J Couch, Kamila Czene, Mary B Daly, Peter Devilee, Thilo Dörk, Laure Dossus, Miriam Dwek, Diana M Eccles, Arif B. Ekici, A. Heather Eliassen, Christoph Engel, D Gareth Evans, Anthony Howell, Michael E Jones, Christopher Scott, William J Tapper & Jack A Taylor,
2023, Genome Medicine, 15(7)
Type: article
Suzanne C. Dixon-Suen, Sarah J Lewis, Richard M. Martin, Dallas English, Terry Boyle, Graham Giles, Diana Eccles, William Tapper, Roger Milne & Brigid Lynch,
2022, British Journal of Sports Medicine, 56(20), 1157-1170
Type: article
Isabelle Grootes, Renske Keeman, Fiona M. Blows, Roger Milne, Graham Giles, Anthony Swerdlow, Diana Eccles & William Tapper,
2022, European Journal of Cancer, 173, 178-193
Type: article
Teaching
Dr Tapper is the Module lead for 'Genomic Technologies and Basic Informatics' and 'Genomic Informatics' for the MSc in Genomics. He delivers lectures for several modules, supervises MSc, PhD and iPhD students and marks their research projects.
Dr Tapper contributes to undergraduate teaching of Medicine (BM5) via his role as the Head of Feild for Genetics and as a Personal Academic tutor. He also supervises and marks third year student projects.