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Dr Chris Hanley

 BSc, MRes, PhD
Associate Professor

Research interests

  • Tumour microenvironment
  • Fibroblasts and the Extracellular Matrix
  • Quantitative Cell Biology

More research

Accepting applications from PhD students.

Connect with Chris

Email: [email protected]

ORCID

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Research interests (for researchers only) 
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ORCID ID 
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Accepting PhD applicants (for researchers only) 
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About

Chris Hanley graduated from Imperial College London with a Biochemistry BSc in 2008. This was followed by an MRes (2011) and PhD (2014) in cancer research from the University of Southampton, including a period of study at the University of Wisconsin-Madison. Following his PhD, Chris has worked as a post-doctoral researcher at the University of Southampton Cancer Sciences Unit and at the Johns Hopkins Centre for Cell Dynamics.

Dr. Hanley’s research aims to understand how the tumour microenvironment influences cancer progression. Particularly focussing on the the role of cancer associated fibroblasts (CAFs). To examine these processes, state-of-the-art methods for analysing human tissue samples are used: including single-cell (sc)RNA-Sequencing; digital pathology analysis of multiplexed immunostaining and 3D organotypic co-cultures that incorporate autologous tumour organoids and stromal cells.

A significant achievement in this work was the identification of NAD(P)H Oxidase 4 (NOX4) as a therapeutic target.  Following this discovery, the use of NOX inhibitors to treat cancers has been patented (Hanley. CJ co-inventor - WO2019086579) and clinical trials are in development to test NOX4 inhibitor efficacy in cancer.

Qualifications

BSc, Imperial College London 2008

MRes, University of Southampton 2011

PhD, University of Southampton 2014

 

 

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