Research group

Interdisciplinary Musculoskeletal Health

4 Stained femur cross sections

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

About

With expertise in regenerative medicine, physiology, engineering, orthopaedics, prosthetics and orthotics, rehabilitation and assistive technologies, epidemiology and clinical trial design, we aim to improve lives by delivering improved treatments, increasing the speed to market of musculoskeletal-focused technology and training the next generation of scientists and engineers. 

The population across the globe is living longer, which brings a number of healthcare challenges, especially in musculoskeletal health. The burden of age-related disease and injury is rising rapidly, having a detrimental impact on people’s quality of life and increasing the costs of healthcare provision. Loss of muscle mass and function is the leading reason for loss of independence in later life, and causes impaired mobility, falls, fractures, physical disability, increased insulin resistance and associated co-morbidities, and mortality. The number of hip fractures is expected to rise to 6.3 million by 2050 and the number of diabetic lower limb amputations has now risen to 7,000 per year in the UK and over 70,000 in the USA. 

The University is working to meet these challenges by creating networks of experts working in interdisciplinary musculoskeletal health research to develop new technologies, interventions and practices that will have a positive effect on people’s lives:

  • FortisNet is an interdisciplinary research network of clinical, academic and industrial partners that aims to develop products and services to transform musculoskeletal health. Launched in 2016, we have fostered over 50 new collaborations with other universities from across the UK, the NHS and industry. We have developed courses with national partners to help innovators understand how to bring medical technologies to market, and through investment in interdisciplinary studentships we are working to dissolve discipline boundaries, to train a new generation of life scientists and engineers for the benefit of society.
  • MyAge (Muscle resilience across the life course: from cells to society) is one of eleven UK Ageing Networks, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council. Led by the Institute for Life Sciences, together with partners from Birmingham, Nottingham and Imperial, the network will guide the future of muscle resilience research through roadmap development and interdisciplinary collaboration.

Research highlights

Preventing the transmission of non-communicable disease risk between generations

Research from the Developmental Origins of Health and Disease Centre demonstrates how the diet and lifestyle choices of prospective parents and pregnant mothers can affect the long-term health of their children.

Using nanoclay gel to regrow, repair and replace damaged cells

Southampton researchers have developed an innovative medical clay that can be used to apply regenerative medicine to patients with musculoskeletal conditions.

People, projects and publications

People

Professor Phyllis Lam

Professor

Research interests

  • Dr. Lam's research interest lies in the functional roles of microorganisms in biogeochemical cycling, particularly the nitrogen and carbon cycles, in diverse marine and aquatic systems. In collaboration with researchers inside and outside the university, her work integrates state-of-the-art molecular ecological techniques, stable isotopic analyses, process rate measurements, hypothesis-driven experimentation and modelling, to disentangle complex microbial interactions and their impacts on biogeochemical environments especially in the context of global change.
  • Current research topics include:
  • Shortcuts in the nitrogen cycle – novel pathways and microbial players for nitrogen remineralisation in the ocean’s twilight zoneMicrobial carbon remineralisation pathways and fluxes in the mesopelagic oceanUsing proteomics tools to disentangle active microbial nitrogen and carbon cycling processes in oceanic oxygen minimum zonesImportance of particle-associated microeukaryotes on the efficiency of oceanic biological carbon pumpMicrobial production and consumption pathways of greenhouse gases
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Mrs Rachel Dadswell

Principal Teaching Fellow
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Dr Rafael Mestre PhD, MSc, BSc

Lecturer

Research interests

  • Responsible Research and Innovation of emergent technologies
  • Multimodal machine learning and Natural Language Processing
  • Computational social science

Accepting applications from PhD students

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Dr Rahman Attar SMIEEE, MIET, FHEA, PhD, MPhil, BEng

Lecturer

Accepting applications from PhD students

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Dr Rahul Tare

Lecturer

Research interests

  • Human stem cells
  • Skeletal development
  • Tissue engineering primarily, cartilage tissue engineering

Accepting applications from PhD students

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Professor Raimund Ober

Prof of Imaging & Biomedical Engineering
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Dr Ralph Gordon BSc, MSc, PhD, FHEA

Postdoctoral Research Fellow

Research interests

  • Thermal and Exercise Physiology
  • Heat Acclimation/Acclimatization
  • Skin Cooling

Accepting applications from PhD students

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Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 
  • Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.
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Professor Rebecca Hoyle

Assoc Vice-President Interdisc Research

Research interests

  • Multimorbidity across the lifecourse
  • Cooperation in social networks and evolution of cooperation
  • Quantitative genetics of transgenerational effects

Accepting applications from PhD students

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Dr Reuben Pengelly PhD, SFHEA

Principal Teaching Fellow

Research interests

  • Student attitudes towards academic integrity
  • Splicing regulation of metal binding proteins

Accepting applications from PhD students

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Related research institutes, centres and groups

Related research institutes, centres and groups

Connect with us

We welcome new members. To join, or find out more about FortisNet or MyAge, please email the Institute for Life Sciences team.