Research project

B Linclau - IB Catalyst - BB/M028941/1

Research groups:

Chemical Biology, Diagnostics and Therapeutics

Organic Chemistry, Synthesis, Catalysis
Other researchers:

Dr Seung Lee
Research funder:

Biotechnology & Biological Sciences Research Council
Status:

Not active

Staff

Other researchers

Dr Seung Lee

Associate Professor

Research interests

Chemical biology
Antimicrobial resistance
Glycan processing enzymes

Connect with Seung

Email: [email protected]

Collaborating research institutes, centres and groups

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Obtaining pure ¹H NMR spectra of individual pyranose and furanose anomers of reducing deoxyfluorinated sugars

Gabija Poškaitė, David E. Wheatley, Neil Wells, Bruno Linclau & Davy Sinnaeve, 2023, Journal of Organic Chemistry, 88(19), 13908-13925

DOI: 10.1021/acs.joc.3c01503

Type: article

Reverse thiophosphorylase activity of a glycoside phosphorylase in the synthesis of an unnatural Manβ1,4GlcNAc library

2023, Chemical Science, 14(42), 11638-11646

DOI: 10.1039/d3sc04169g

Type: article

Synthesis and structural characteristics of all mono- and difluorinated 4,6-dideoxy-d-xylo-hexopyranoses

David Wheatley, Clement Q Fontenelle, Rama krishna K Kuppala, Robert Szpera, Edward L. Briggs, Jean B Vendeville, Neil J. Wells, Mark Light & Bruno Linclau, 2021, Journal of Organic Chemistry, 86(11), 7725–7756

DOI: 10.1021/acs.joc.1c00796

Type: article

Introducing affinity and selectivity into galectin-targeting nanoparticles with fluorinated glycan ligands

Sarah-Jane Richards, Tessa Keenan, Jean-Baptiste Vendeville, David Wheatley, Harriet Chidwick, Darshita Budhadev, Claire Council, Claire S. Webster, Helene Ledru, Alexander Baker, Marc Walker, M. Carmen Galan, Bruno Linclau, Martin A. Fascione & Matthew I. Gibson, 2020, Chemical Science, 12(3), 905-910

DOI: 10.1039/D0SC05360K

Type: article

Profiling substrate promiscuity of wild-type sugar kinases for multifluorinated monosaccharides

2020, Cell Chemical Biology, 27(9), 1199-1206.e5

DOI: 10.1016/j.chembiol.2020.06.005

Type: article