Research project

B Linclau - IB Catalyst - BB/M028941/1

Research groups:

Chemical Biology, Diagnostics and Therapeutics

Organic Chemistry, Synthesis, Catalysis
Other researchers:

Dr Seung Lee
Research funder:

Biotechnology & Biological Sciences Research Council
Status:

Not active

Staff

Other researchers

Dr Seung Lee

Associate Professor

Research interests

Chemical biology
Antimicrobial resistance
Glycan processing enzymes

Connect with Seung

Email: [email protected]

Collaborating research institutes, centres and groups

Organic Chemistry, Synthesis, Catalysis

We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.

Research outputs

Chemoenzymatic synthesis of 3-deoxy-3-fluoro-L-fucose and its enzymatic incorporation into glycoconjugates

Pablo Valverde Sanchez, Jean B Vendeville, Kristian Hollingsworth, Ashley Mattey, Tessa Keenan, Harriet Chidwick, Helene Ledru, Kler Huonnic, Kun Huang, Mark Light, Nicholas Turner, Jesus Jimenez-Barbero, M. Carmen Galan, Martin A. Fascione, Sabine L. Flitsch, W. Bruce Turnbull & Bruno Linclau, 2020, Chemical Communications, 56(47), 6408-6411

DOI: 10.1039/d0cc02209h

Type: article

Enzymatic glycosylation involving fluorinated carbohydrates

Claire Council, Kelly J. Kilpin, Jessica S Gusthart, Sarah A. Allman, Bruno Linclau & Seung Seo Lee, 2020, Organic & Biomolecular Chemistry, 18(18), 3423-3451

DOI: 10.1039/D0OB00436G

Type: article

Molecular insights into DC-SIGN binding to self-antigens: the interaction with the blood group A/B antigens

2019, ACS Chemical Biology, 14(7), 1660-1671

DOI: 10.1021/acschembio.9b00458

Type: article

Synthesis of vicinal dideoxy-difluorinated galactoses

Julien GJ Malassis, Jean Vendeville, Qui-Hien Nguyen, Marie Boujon, Quentin Gaignard-Gaillard, Mark Light & Bruno Linclau, 2019, Organic & Biomolecular Chemistry

DOI: 10.1039/C9OB00707E

Type: article

Isolation and characterisation of an unexpected byproduct in the regioselective butane diacetal protection of α-methyl galactopyranoside

Clement Q. Fontenelle, Ramakrishna Kuppala, Mark Light & Bruno Linclau, 2018, Carbohydrate Research, 455, 14-17

DOI: 10.1016/j.carres.2017.10.023

Type: article