Research project

Investigating the role of PIP4K2B, nuclear phosphoinositides and TAF3 in transcription and genome organisation during myogenic differentiation

Lead researchers:

Professor Nullin Divecha
Research funder:

Biotechnology & Biological Sciences Research Council
Status:

Not active

Staff

Lead researchers

Professor Nullin Divecha

Professor of Cellular Signalling

Connect with Nullin

Email: [email protected]

Research outputs

Mechanisms of SARS-CoV-2 inactivation using UVC laser radiation

George Devitt, Peter B. Johnson, Niall Hanrahan, Simon I.R. Lane, Magdalena C. Vidale, Bhavwanti Sheth, Joel D. Allen, Maria V. Humbert, Cosma M. Spalluto, Rodolphe C. Herve, Karl Staples, Jonathan J. West, Robert Forster, Nullin Divecha, Chris McCormick, Max Crispin, Nils Hempler, Graeme P.A. Malcolm & Sumeet Mahajan, 2024, ACS Photonics, 11(1), 42-52

DOI: 10.1021/acsphotonics.3c00828

Type: article

PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1

A. Poli, F.A. Pennacchio, A. Ghisleni, M. di Gennaro, M. Lecacheur, P. Nastaly, M. Crestani, F.M. Pramotton, F. Iannelli, G. Beznusenko, A. A Mironov, V. Panzetta, S. Fusco, B. Sheth, D. Poulikakos, A. Ferrari, N. Gauthier, P.A. Netti, N. Divecha & P. Maiuri, 2023, Nature Communications, 14(1)

DOI: 10.1038/s41467-023-37064-0

Type: article

Identification and optimization of a novel series of selective PIP5K inhibitors

D.M. Andrews, S. Cartic, S. Cosulich, N. Divecha, P. Faulder, V. Flemington, O. Kern, J.G. Kettle, E. MacDonald, J. McKelvie, K.G. Pike, B. Roberts, R. Rowlinson, J.M. Agnos, M. Stockley, M.E. Swarbrick, I. Treinies & M.J. Waring, 2021, Bioorganic & Medicinal Chemistry, 54

DOI: 10.1016/j.bmc.2021.116557

Type: article

PIP4Ks impact on PI3K, FOXP3, and UHRF1 signaling and modulate human regulatory T cell proliferation and immunosuppressive activity

Alessandro Poli, Shidqiyyah Abdul-hamid, Antonio Enrico Zaurito, Francesca Campagnoli, Valeria Bevilacqua, Bhavwanti Sheth, Roberta Fiume, Massimiliano Pagani, Sergio Abrignani & Nullin Divecha, 2021, Proceedings of the National Academy of Sciences, 118(31), e2010053118

DOI: 10.1073/pnas.2010053118

Type: article

Modulating phosphoinositide profiles as a roadmap for treatment in acute myeloid leukemia

S. Ratti, C. Evangelisti, S. Mongiorgi, A. De Stefano, A. Fazio, F. Bonomini, M.Y. Follo, I. Faenza, L. Manzoli, B. Sheth, M.C. Vidalle, S.T. Kimber, N. Divecha, L. Cocco & R. Fiume, 2021, Frontiers in Oncology, 11

DOI: 10.3389/fonc.2021.678824

Type: article