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Research project

Investigation of the epithelial-mescenchyme trophic unit (EMTU) in lung firbrosis

Staff

Lead researcher

Professor Donna Davies

Prof in Resp. Cell & Molecular Biology

Research interests

  • Mechanisms of lung diseases
  • Viral-induced exacerbations of lung disease
  • Asthma
Connect with Donna

Email: [email protected]

Research outputs

Towards an artificial human lung
Maria Victoria Humbert, Cosma Mirella Spalluto, Joseph Bell, Cornelia Blume, Franco Conforti, Elizabeth R Davies, Lareb S N Dean, Paul Elkington, Hans Michael Haitchi, Claire Jackson, Mark G Jones, Matthew Loxham, Jane S Lucas, Hywel Morgan, Marta Polak, Karl J Staples, Emily J Swindle, Liku Tezera, Alastair Watson & Tom M A Wilkinson, 2022, The European respiratory journal, 60(6)
DOI: 10.1183/13993003.00455-2022
Type: article
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis
Christopher J. Brereton, Liudi Yao, Elizabeth R. Davies, Yilu Zhou, Milica Vukmirovic, Joseph A. Bell, Siyuan Wang, Robert A. Ridley, Lareb S.N. Dean, Orestis G. Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M. Ewing, Aiman Alzetani, Benjamin G. Marshall, Sophie V. Fletcher, Philipp J. Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J. Schofield, Matthew Loxham, Donna E. Davies, Yihua Wang & Mark G. Jones, 2022, eLife, 11
DOI: 10.7554/eLife.69348
Type: article
Bidirectional epithelial-mesenchymal crosstalk provides self-sustaining profibrotic signals in pulmonary fibrosis
Liudi Yao, Yilu Zhou, Juanjuan Li, Leanne Wickens, Franco Conforti, Anna Simron Rattu, Fathima M Ibrahim, Aiman Alzetani, Benjamin Marshall, Sophie Fletcher, David Hancock, Timothy Wallis, Julian Downward, Robert Ewing, Luca Richeldi, Paul Skipp, Donna Davies, Mark Glynne Jones & Yihua Wang, 2021, Journal of Biological Chemistry, 297(3)
DOI: 10.1016/j.jbc.2021.101096
Type: article
Paracrine SPARC signaling dysregulates alveolar epithelial barrier integrity and function in lung fibrosis
Franco Conforti, Robert Ridley, Christopher J Brereton, Aiman Alzetani, Mark Jones, Donna Davies, Paul Skipp, Yihua Wang, Christian Ottensmeier, B. Marshall, Sophie Fletcher, Luca Richeldi & Benjamin Johnson, 2020, Cell Death and Discovery, 6
DOI: 10.1038/s41420-020-0289-9
Type: article
Autophagy inhibition-mediated epithelial–mesenchymal transition augments local myofibroblast differentiation in pulmonary fibrosis
Charlotte Hill, Juanjuan Li, Dian Liu, Franco Conforti, Christopher J. Brereton, Liudi Yao, Yilu Zhou, Aiman Alzetani, Serena J. Chee, Ben G. Marshall, Sophie V. Fletcher, David Hancock, Christian H. Ottensmeier, Andrew J. Steele, Julian Downward, Luca Richeldi, Xin Lu, Donna E. Davies, Mark G. Jones & Yihua Wang, 2019, Cell Death and Disease, 10(8)
DOI: 10.1038/s41419-019-1820-x
Type: article