Research group

Interdisciplinary Musculoskeletal Health

4 Stained femur cross sections

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

About

With expertise in regenerative medicine, physiology, engineering, orthopaedics, prosthetics and orthotics, rehabilitation and assistive technologies, epidemiology and clinical trial design, we aim to improve lives by delivering improved treatments, increasing the speed to market of musculoskeletal-focused technology and training the next generation of scientists and engineers. 

The population across the globe is living longer, which brings a number of healthcare challenges, especially in musculoskeletal health. The burden of age-related disease and injury is rising rapidly, having a detrimental impact on people’s quality of life and increasing the costs of healthcare provision. Loss of muscle mass and function is the leading reason for loss of independence in later life, and causes impaired mobility, falls, fractures, physical disability, increased insulin resistance and associated co-morbidities, and mortality. The number of hip fractures is expected to rise to 6.3 million by 2050 and the number of diabetic lower limb amputations has now risen to 7,000 per year in the UK and over 70,000 in the USA. 

The University is working to meet these challenges by creating networks of experts working in interdisciplinary musculoskeletal health research to develop new technologies, interventions and practices that will have a positive effect on people’s lives:

  • FortisNet is an interdisciplinary research network of clinical, academic and industrial partners that aims to develop products and services to transform musculoskeletal health. Launched in 2016, we have fostered over 50 new collaborations with other universities from across the UK, the NHS and industry. We have developed courses with national partners to help innovators understand how to bring medical technologies to market, and through investment in interdisciplinary studentships we are working to dissolve discipline boundaries, to train a new generation of life scientists and engineers for the benefit of society.
  • MyAge (Muscle resilience across the life course: from cells to society) is one of eleven UK Ageing Networks, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council. Led by the Institute for Life Sciences, together with partners from Birmingham, Nottingham and Imperial, the network will guide the future of muscle resilience research through roadmap development and interdisciplinary collaboration.

Research highlights

Preventing the transmission of non-communicable disease risk between generations

Research from the Developmental Origins of Health and Disease Centre demonstrates how the diet and lifestyle choices of prospective parents and pregnant mothers can affect the long-term health of their children.

Using nanoclay gel to regrow, repair and replace damaged cells

Southampton researchers have developed an innovative medical clay that can be used to apply regenerative medicine to patients with musculoskeletal conditions.

People, projects and publications

People

Dr Ingi Iusmen

Associate Professor

Research interests

  • children's rights
  • child migration
  • public policy

Accepting applications from PhD students

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Professor Ingrid Muller BSc, MSc, PhD, CPsychol, FHEA

Professor

Research interests

  • Self-management of long-term conditions
  • Behavioural health interventions
  • Digital health

Accepting applications from PhD students

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Dr Ioannis Zeimpekis

Associate Professor

Accepting applications from PhD students

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Dr Irina Mohorianu

Associate Professor
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Dr Iris Nandhakumar

Associate Professor

Research interests

  • Scanning Probe Microscopy
  • Carbon nanotubes
  • Nanoscale materials

Accepting applications from PhD students

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Professor Ivan Haigh

Professor

Research interests

  • I currently have 8 active research grants (4 as principle investigator (PI)) worth £4.8M. 
  • I am the PI on two international grants that started in 2019, both looking at compound flooding. Compound flooding (when the combination, or successive occurrence of, two or more hazard events leads to an extreme impact e.g., coastal and fluvial flooding), can greatly exacerbate the adverse consequences associated with flooding in coastal regions and yet it remains under-appreciated and poorly understood. In the £788k NERC- and NSF- (US National Science Foundation) funded CHANCE project, I am leading a team (working alongside researchers from the University of Central Florida), to deliver a new integrated approach to make a step-change in our understanding, and prediction of, the source mechanisms driving compound flood events in coastal areas around the North Atlantic basin. In the £575k NERC- and NAFOSTED- (Vietnam’s National Foundation for Science and Technology Development) funded project, I am leading a team that is working with colleagues in Vietnam to map and characterise present, and predict future, flood risk from coastal, fluvial, and surface sources and, uniquely, to assess the risk of compound flooding across the Mekong delta; one of the three most vulnerable deltas in the world. I am also the PI on a grant, which started in 2021. In this 41k project, funded by the Dutch Ministry of Infrastructure and Water Management (Rijkswaterstaat), we are assessing past and future closures of the six storm surge barriers in the Netherlands.
  • In 2021, I was awarded a 3-year (50% of my time) prestigious Knowledge Exchange Fellowship funded by NERC (UK’s Natural Environmental Research Council) and worth £154k. This fellowship builds strongly on my prior research and the overall goal is to provide guidance and tools that will help storm surge barrier operators better prepare for the impacts of climate change across every area of their operation now and into the future. Within the fellowship I am working primary with the UK Environment Agency (EA) and the Dutch Ministry of Infrastructure and Water Management (Rijkswaterstaat). However, to ensure the work undertaken can benefit all the existing (and planned) surge barriers around the world, I am also working closely with I-STORM. I-STORM is an international knowledge sharing network for professionals relating to the management, operation and maintenance of storm surge barriers, and has representation from all the surge barriers worldwide.

Accepting applications from PhD students

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Professor Ivo Tews

Professor

Research interests

  • Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit
  • Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections
  • Cancer immunology: together with Cancer Immunology at Southampton we use a structure based apporach in developing novel cancer therapie
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Professor Jacek Brodzki

Head of School

Research interests

  • Topological data analysis
  • Applications of topology to medicine, biology, chemistry, physics, computer science
  • Noncommutative Geometry

Accepting applications from PhD students

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Mr Jack Stubbs MSci

Research interests

  • Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP synthase complexTime-resolved serial crystallography: experiments using microcrystals at room temperature, performed at synchrotrons and XFELsDroplet microfluidics: producing homogenous microcrystal slurries for serial experiments
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Dr Jacqui Prieto RN, PhD

Associate Professor

Research interests

  • Preventing urinary tract infection and catheter-associated urinary tract infection
  • Optimising hygiene behaviours in healthcare
  • Understanding patients' experiences of healthcare associated infection

Accepting applications from PhD students

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Related research institutes, centres and groups

Related research institutes, centres and groups

Connect with us

We welcome new members. To join, or find out more about FortisNet or MyAge, please email the Institute for Life Sciences team.