Research group

Interdisciplinary Musculoskeletal Health

4 Stained femur cross sections

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

About

With expertise in regenerative medicine, physiology, engineering, orthopaedics, prosthetics and orthotics, rehabilitation and assistive technologies, epidemiology and clinical trial design, we aim to improve lives by delivering improved treatments, increasing the speed to market of musculoskeletal-focused technology and training the next generation of scientists and engineers. 

The population across the globe is living longer, which brings a number of healthcare challenges, especially in musculoskeletal health. The burden of age-related disease and injury is rising rapidly, having a detrimental impact on people’s quality of life and increasing the costs of healthcare provision. Loss of muscle mass and function is the leading reason for loss of independence in later life, and causes impaired mobility, falls, fractures, physical disability, increased insulin resistance and associated co-morbidities, and mortality. The number of hip fractures is expected to rise to 6.3 million by 2050 and the number of diabetic lower limb amputations has now risen to 7,000 per year in the UK and over 70,000 in the USA. 

The University is working to meet these challenges by creating networks of experts working in interdisciplinary musculoskeletal health research to develop new technologies, interventions and practices that will have a positive effect on people’s lives:

  • FortisNet is an interdisciplinary research network of clinical, academic and industrial partners that aims to develop products and services to transform musculoskeletal health. Launched in 2016, we have fostered over 50 new collaborations with other universities from across the UK, the NHS and industry. We have developed courses with national partners to help innovators understand how to bring medical technologies to market, and through investment in interdisciplinary studentships we are working to dissolve discipline boundaries, to train a new generation of life scientists and engineers for the benefit of society.
  • MyAge (Muscle resilience across the life course: from cells to society) is one of eleven UK Ageing Networks, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council. Led by the Institute for Life Sciences, together with partners from Birmingham, Nottingham and Imperial, the network will guide the future of muscle resilience research through roadmap development and interdisciplinary collaboration.

Research highlights

Preventing the transmission of non-communicable disease risk between generations

Research from the Developmental Origins of Health and Disease Centre demonstrates how the diet and lifestyle choices of prospective parents and pregnant mothers can affect the long-term health of their children.

Using nanoclay gel to regrow, repair and replace damaged cells

Southampton researchers have developed an innovative medical clay that can be used to apply regenerative medicine to patients with musculoskeletal conditions.

People, projects and publications

People

Dr Jagmohan Chauhan

Lecturer in Computer Science

Research interests

  • Digital healthcare
  • Embedded AI
  • Sensing

Accepting applications from PhD students

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Dr James Ashton

Associate Professor

Research interests

  • Inflammatory Bowel Disease
  • Paediatrics
  • Big Data

Accepting applications from PhD students

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Professor James Batchelor

Associate Dean International

Research interests

  • Public Health / Health Systems
  • Clinical Research Infastrcuture
  • Clinical Informatics / Health Infromatics

Accepting applications from PhD students

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Dr James Gavin

Lecturer

Research interests

  • Musculoskeletal conditions
  • Physical activity
  • Self-management

Accepting applications from PhD students

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Dr Jan Janouskovec PhD

Lecturer in Ecology

Research interests

  • Protist diversity and ecology
  • Evolution of eukaryotic cells
  • Metabolism in plastids & mitochondria

Accepting applications from PhD students

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Professor Jana Kreppner

Professor

Research interests

  • Jana's work focusses on the impact of early experience on development. She is particularly interested in the role of relationship experiences, especially caregiver-child and peer/friend relationships, in typical and atypical development. Jana studies factors that influence relationship experiences as well as the effects and correlates of such relationship experiences on children’s development. Jana uses this knowledge to inform the development of relationship-based interventions to promote children and young people’s wellbeing. Her research has been funded by the ESRC, NIHR, the Waterloo Foundation and the Welcome Trust. Jana's research uses both quantitative and qualitative methods. She has extensive experience conducting longitudinal research across childhood, adolescence and young adulthood. Jana is currently involved in a range of interdisciplinary collaborations which span Psychiatry, Paediatric Neurology, Psychology, Education, Social Work, Public Policy, and Law.
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Dr Jane Cleal PhD

Associate Professor

Research interests

  • Areas of Scientific Expertise:
  • Reproductive Cell Biology – Fundamental mechanisms of cell biology in placenta and endometrium and the impact on the intra-uterine environment, fetal development and lifelong health.Regulation of Reproductive Cell Biology – Maternal exposures and molecular regulation of cellular gene expression, phenotype and function in placenta and endometrium and the clinical translation.Disease/phenotype – Fetal growth, Obesity, Cardiometabolic programming, Subfertility, Recurrent pregnancy loss.Cellular mechanisms – Membrane transport, endocytosis, vesicular transport & signalling, gene transcription, microRNA biology, epigenetic regulation.Vitamin D - Transport, regulation, metabolism and signalling.

Accepting applications from PhD students

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Dr Jane Gibson

Associate Professor
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Professor Jane Lucas MD, PhD, FRCPCH, FERS

Professor of Paediatric Respiratory Med
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Related research institutes, centres and groups

Related research institutes, centres and groups

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We welcome new members. To join, or find out more about FortisNet or MyAge, please email the Institute for Life Sciences team.