Research group

Interdisciplinary Musculoskeletal Health

4 Stained femur cross sections

The University hosts a substantial interdisciplinary community of researchers working to transform musculoskeletal health across the life course.

About

With expertise in regenerative medicine, physiology, engineering, orthopaedics, prosthetics and orthotics, rehabilitation and assistive technologies, epidemiology and clinical trial design, we aim to improve lives by delivering improved treatments, increasing the speed to market of musculoskeletal-focused technology and training the next generation of scientists and engineers. 

The population across the globe is living longer, which brings a number of healthcare challenges, especially in musculoskeletal health. The burden of age-related disease and injury is rising rapidly, having a detrimental impact on people’s quality of life and increasing the costs of healthcare provision. Loss of muscle mass and function is the leading reason for loss of independence in later life, and causes impaired mobility, falls, fractures, physical disability, increased insulin resistance and associated co-morbidities, and mortality. The number of hip fractures is expected to rise to 6.3 million by 2050 and the number of diabetic lower limb amputations has now risen to 7,000 per year in the UK and over 70,000 in the USA. 

The University is working to meet these challenges by creating networks of experts working in interdisciplinary musculoskeletal health research to develop new technologies, interventions and practices that will have a positive effect on people’s lives:

  • FortisNet is an interdisciplinary research network of clinical, academic and industrial partners that aims to develop products and services to transform musculoskeletal health. Launched in 2016, we have fostered over 50 new collaborations with other universities from across the UK, the NHS and industry. We have developed courses with national partners to help innovators understand how to bring medical technologies to market, and through investment in interdisciplinary studentships we are working to dissolve discipline boundaries, to train a new generation of life scientists and engineers for the benefit of society.
  • MyAge (Muscle resilience across the life course: from cells to society) is one of eleven UK Ageing Networks, funded by the Biotechnology and Biological Sciences Research Council and Medical Research Council. Led by the Institute for Life Sciences, together with partners from Birmingham, Nottingham and Imperial, the network will guide the future of muscle resilience research through roadmap development and interdisciplinary collaboration.

Research highlights

Preventing the transmission of non-communicable disease risk between generations

Research from the Developmental Origins of Health and Disease Centre demonstrates how the diet and lifestyle choices of prospective parents and pregnant mothers can affect the long-term health of their children.

Using nanoclay gel to regrow, repair and replace damaged cells

Southampton researchers have developed an innovative medical clay that can be used to apply regenerative medicine to patients with musculoskeletal conditions.

People, projects and publications

People

Professor Jonathan Essex

Professor

Accepting applications from PhD students

Connect with Jonathan

Dr Jonathan Swann

Professor of Biomolecular Medicine

Accepting applications from PhD students

Connect with Jonathan

Dr Jonathan West

Associate Professor

Research interests

  • Time-Resolved Structural Biology The emergence of serial crystallography brings many exciting possibilities for structural biology but also brings the challenge of preparing many thousands of sub-micron crystals. To address this, we are working with Ivo Tews and Allen Orville to develop high throughput droplet microfluidic systems. Here volumetric confinement of the phase diagram defines growth limits for producing monodisperse protein crystals. Beyond this, the microfluidic processors can be interfaced with the beam line to enable dynamic structural biology.

Accepting applications from PhD students

Connect with Jonathan

Dr Jorn Cheney

Lecturer in Natural Sciences

Research interests

  • Locomotion
  • Wing morphing
  • Tissues and tissue mechanics

Accepting applications from PhD students

Connect with Jorn

Dr Jorn Lakowski

Lecturer

Research interests

  • Retinal Disease Modelling
  • Retinal Development
  • Drug Screening

Accepting applications from PhD students

Connect with Jorn

Professor Judith Holloway BSc (Hons), PhD, PGCert, PFHEA, NTF

Professorial Fellow in Allergy

Research interests

  • HACASE: A simple effective educational model for session design: Prof Holloway has designed an educational model for teaching which is applicable across any teaching activity. Current research activity is evaluating its effectiveness in clinical teaching including allergy to different learners from patients to undergraduates and multi-professional healthcare professionals.
  • MSc Allergy education: Prof Holloway's team explore innovations and the effectiveness of teaching on the MSc Allergy, to disseminate their experiences for the benefit of other courses around the University and more widely. 
  • Allergy bitesize education (short e-courses for CPD): Prof Holloway has led the development of short e-courses, including an Anaphylaxis Toolkit which provide Gain and Train learning for healthcare professionals on how to effectively teach patients this important topic.
Connect with Judith

Professor Juerg Matter

Professor of Geoengineering&Carbon Manag
Connect with Juerg

Professor Juliet Gray

Professor

Research interests

  • Fc modification of monoclonal antibodies to improve effector function
Connect with Juliet

Professor Kai Yang

Professor

Research interests

  • Electronic textile materials and manufacturing
  • Wearable medical devices (e.g. stroke rehabilitation, pain management)
  • Digital healthcare

Accepting applications from PhD students

Connect with Kai

Professor Karl Staples PhD CBiol FRSB FHEA

Prof Resp Immunology & Pharmacology

Research interests

  • Chronic Respiratory Disease e.g. Asthma, COPD
  • Host-pathogen Interactions
  • Ex vivo models of the human lung
Connect with Karl

Related research institutes, centres and groups

Related research institutes, centres and groups

Connect with us

We welcome new members. To join, or find out more about FortisNet or MyAge, please email the Institute for Life Sciences team.