Research
Research groups
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Research interests
- The demographic of populations worldwide is changing. People are living longer but with more years with affected by disability in the last two decades of life. The societal and economic consequences of this change are not being well managed. There is a lag in the development of health interventions and a need for rapid learning for future health and infrastructure planning. Typically, people in poorer economic situations are disproportionately affected by disability in later life.
- Hearing loss and dementia: I lead multidisciplinary research focussed on hearing loss, the use of cochlear implants to restore hearing in otherwise deaf people and the interaction between hearing loss and dementia.
- My focus is understanding cellular mechanisms in these conditions and also how the learning and methodologies used to investigate this can be applied across discipline boundaries. I am driving the implementation of data science methodologies for improved management of people who hear with cochlear implants and for the identification of early indicators of cognitive decline. I am championing the engagement of patients in research and as ambassadors to increase awareness of healthcare interventions amongst hard to reach and marginalised communities.
- Nanomedicine: Drug efficacy is affected by the way the drug is delivered to its site of action. Packaging, at the nanoscale, within biocompatible polymers can increase efficacy, reduce off-target effects and enable delivery across biological barriers such as within the inner ear.
- My research in collaboration with Nick Evans (Medicine), Seung Lee (Chemistry) and Adam Wheelan (DSTL) is to determine whether exisiting antimicrobials, repackaged within polymersomes, show improved efficacy against hard to treat persistent bacterial infections.
Research projects
Active projects
Completed projects
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Sponsor: EPSRC
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Sponsor: Gerald Kerkut Charitable Trust
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Sponsor: Alzheimers Research UK
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Sponsor: Medical Research Council
Sponsor: Medical Research Council
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Sponsor: Wessex Medical Research
Y Cheong Infertility Research Trust Enhanced detection of endometriosis using targeted nanoparticles
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Sponsor: The Infertility Research Trust
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Sponsor: Wessex Medical Research
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Sponsor: Leverhulme Trust
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Sponsor: Med-El Elektromedizinische Gerate Gesellschaft m.b.H.
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