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Research project

Bioengineering to combat the tuberculosis pandemic

Project overview

We will combine engineering and biological approaches to investigate the host-pathogen interaction and identify new therapeutic targets.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

  • tuberculosis
  • immunopathology
  • diagnosis
Connect with Paul

Email: [email protected]

Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Head of Department-Chemical Engineerg

Research interests

  • Microfluidics and Lab-on-a-Chip Technologies
  • Biomedical and Chemical Engineering
  • Nanomaterials
Connect with Xunli

Email: [email protected]

Research outputs

Personal respirators for population level control of the COVID19 pandemic
Paul Elkington & Hywel Morgan, 2020, Journal of Infection, 81(2), 318-356
DOI: 10.1016/j.jinf.2020.04.025
Type: letterEditorial
Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-alpha
Liku Bekele Tezera, Magdalena Bielecka, Paul Ogongo, Naomi Walker, Matthew Ellis, Diana J. Garay-Baquero, Kristian Thomas, MICHAELA REICHMANN, David Johnston, Katalin Wilkinson, Mohamed Ahmed, Sanjay Jogai, Suwan N. Jayasinghe, Robert J. Wilkinson, Salah Mansour, Gareth Thomas, Christian Ottensmeier, Alasdair Leslie & Paul Elkington, 2020, eLife, 9
DOI: 10.7554/eLife.52668
Type: article
Reconsidering the optimal immune response to Mycobacterium tuberculosis
Liku Bekele Tezera, Salah Mansour & Paul Elkington, 2019, American Journal of Respiratory and Critical Care Medicine, 201(4)
DOI: 10.1164/rccm.201908-1506PP
Type: review
In vitro granuloma models of tuberculosis
Paul Elkington, Maria Lerm, Nidhi Kapoor, Robert Mahon, Elsje Pienaar, Dongeun Huh, Deepak Kaushal & Larry Schlesinger, 2019, Journal of Infectious Diseases, 219(12), 1858–1866
DOI: 10.1093/infdis/jiz020
Type: review
Implications of tuberculosis reactivation after immune checkpoint inhibition
Paul Elkington, Adrian Bateman, Gareth Thomas & Christian Ottensmeier, 2018, American Journal of Respiratory and Critical Care Medicine, 198(11), 1451-1453
DOI: 10.1164/rccm.201807-1250LE
Type: letterEditorial