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Research project

(Fellowship) Investigating the trigger for fibroblast senescence in colorectal cancer: a novel

Staff

Lead researchers

Dr Rahul Bhome

Connect with Rahul

Email: [email protected]

Other researchers

Professor Alex Mirnezami

Professor of Surgical Oncology
Connect with Alex

Email: [email protected]

Dr Emre Sayan

Associate Professor

Research interests

  • - The link between EMT and apoptosis/therapy resistance.
  • - Mechanobiology of EMT: How tumour stiffness associates with EMT and creates tumour microenvironment.
  • - How EMT influences non-cancer cells in tumour microenvironment (e.g. T cell recruitment or fibroblast-myofibroblast differentiation).
Connect with Emre

Email: [email protected]

Research outputs

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination
Marco Montagner, Rahul Bhome, Steven Hooper, Probir Chakravarty, Xiao Qin, Jahangir Sufi, Ajay Bhargava, Colin D.H. Ratcliffe, Yutaka Naito, Arianna Pocaterra, Christopher J. Tape & Erik Sahai, 2020, Nature Cell Biology, 22(3), 289-296
DOI: 10.1038/s41556-020-0474-3
Type: letterEditorial
Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC
Rahul Sreekumar, Muhammad Emaduddin, Hajir Al-Saihati, Karwan Moutasim, James Chan, Marcello Spampinato, Rahul Bhome, Ho Ming Yuen, Claudia Mescoli, Alessandro Vitale, Umberto Cillo, Massimo Rugge, John Primrose, Mohammad Abu Hilal, Stephen Thirdborough, Eugene Tulchinsky, Gareth Thomas, Alex Mirnezami & A Emre Sayan, 2019, Cell Death and Disease, 10(10)
DOI: 10.1038/s41419-019-1885-6
Type: article
Transglutaminase-2 mediates the biomechanical properties of the colorectal cancer tissue microenvironment that contribute to disease progression
Robin Delaine-Smith, Nicola Wright, Chris Hanley, Rebecca Hanwell, Rahul Bhome, Marc Bullock, Cole Drifka, Kevin W. Eliceiri, Gareth Thomas, Martin Knight, Alexander Mirnezami & Nicholas Peake, 2019, Cancers, 11(5)
DOI: 10.3390/cancers11050701
Type: article
Long non-coding RNAs within the tumour microenvironment and their role in tumour-stroma cross-talk
Filippo Del Vecchio, Gui Han Lee, Joamir Hawezi, Rahul Bhome, Sian Pugh, Emre Sayan, Gareth Thomas, Graham Packham, John Primrose, Martin Pichler, Alexander Mirnezami, George Calin & Marc Bullock, 2018, Cancer Letters, 421, 94-102
DOI: 10.1016/j.canlet.2018.02.022
Type: review
Exosomal microRNAs (exomiRs)
Rahul Bhome, Filippo Del Vecchio, Gui-Han Lee, Marc D Bullock, John N Primrose, A Emre Sayan & Alex H Mirnezami, 2018, Cancer Letters, 420, 228-235
DOI: 10.1016/j.canlet.2018.02.002
Type: article