Research project

(Fellowship) Investigating the trigger for fibroblast senescence in colorectal cancer: a novel

Lead researchers:

Dr Rahul Bhome
Other researchers:

Professor Alex Mirnezami,

Dr Emre Sayan
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researchers

Dr Rahul Bhome

Connect with Rahul

Email: [email protected]

Other researchers

Professor Alex Mirnezami

Professor of Surgical Oncology

Connect with Alex

Email: [email protected]

Research interests

- The link between EMT and apoptosis/therapy resistance.
- Mechanobiology of EMT: How tumour stiffness associates with EMT and creates tumour microenvironment.
- How EMT influences non-cancer cells in tumour microenvironment (e.g. T cell recruitment or fibroblast-myofibroblast differentiation).

Connect with Emre

Email: [email protected]

Research outputs

Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination

Marco Montagner, Rahul Bhome, Steven Hooper, Probir Chakravarty, Xiao Qin, Jahangir Sufi, Ajay Bhargava, Colin D.H. Ratcliffe, Yutaka Naito, Arianna Pocaterra, Christopher J. Tape & Erik Sahai, 2020, Nature Cell Biology, 22(3), 289-296

DOI: 10.1038/s41556-020-0474-3

Type: letterEditorial

Protein kinase C inhibitors override ZEB1-induced chemoresistance in HCC

Rahul Sreekumar, Muhammad Emaduddin, Hajir Al-Saihati, Karwan Moutasim, James Chan, Marcello Spampinato, Rahul Bhome, Ho Ming Yuen, Claudia Mescoli, Alessandro Vitale, Umberto Cillo, Massimo Rugge, John Primrose, Mohammad Abu Hilal, Stephen Thirdborough, Eugene Tulchinsky, Gareth Thomas, Alex Mirnezami & A Emre Sayan, 2019, Cell Death and Disease, 10(10)

DOI: 10.1038/s41419-019-1885-6

Type: article

Transglutaminase-2 mediates the biomechanical properties of the colorectal cancer tissue microenvironment that contribute to disease progression

Robin Delaine-Smith, Nicola Wright, Chris Hanley, Rebecca Hanwell, Rahul Bhome, Marc Bullock, Cole Drifka, Kevin W. Eliceiri, Gareth Thomas, Martin Knight, Alexander Mirnezami & Nicholas Peake, 2019, Cancers, 11(5)

DOI: 10.3390/cancers11050701

Type: article

Long non-coding RNAs within the tumour microenvironment and their role in tumour-stroma cross-talk

Filippo Del Vecchio, Gui Han Lee, Joamir Hawezi, Rahul Bhome, Sian Pugh, Emre Sayan, Gareth Thomas, Graham Packham, John Primrose, Martin Pichler, Alexander Mirnezami, George Calin & Marc Bullock, 2018, Cancer Letters, 421, 94-102

DOI: 10.1016/j.canlet.2018.02.022

Type: review

Exosomal microRNAs (exomiRs)

Rahul Bhome, Filippo Del Vecchio, Gui-Han Lee, Marc D Bullock, John N Primrose, A Emre Sayan & Alex H Mirnezami, 2018, Cancer Letters, 420, 228-235

DOI: 10.1016/j.canlet.2018.02.002

Type: article