About
Dr Andy van Hateren is a senior post-doctoral research fellow working with Prof Edd James (University of Southampton) and Prof Tim Elliott (University of Oxford).
Dr van Hateren's research is focused on understanding the relationship between Major Histocompatibility Complex class I molecules and their immune receptors. In particular, he is interested in determining the mechanisms of Major Histocompatibility Complex class I peptide selection, and how tapasin and TAPBPR modulate peptide selection.
Dr van Hateren runs a part of the lab in the Life Sciences building. supervising a research assistant as well as students.
Dr van Hateren also presents immunology lectures, facilitates tutorials, is module lead for the research dissertation module on the Cancer Biology and Immunology masters course, supervises students during research projects, and is a personal academic tutor.
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Research
Research interests
- Immunology.
- Cancer.
- MHC I peptide selection.
- Antigen presentation.
- Protein structure and protein dynamics.
Current research
The binding of peptides by Major Histocompatibility Complex class I molecules (MHC I), and their presentation to cytotoxic T cells, is an integral component of the adaptive immune system, providing protection from intracellular pathogens and cancer.
MHC I molecules are highly polymorphic, with each MHC I allotype binding a different cohort of peptides. MHC I molecules become loaded with peptides in the endoplasmic reticulum of a cell, in a process that is assisted by a macromolecular peptide loading complex. A key constituent of this peptide loading complex is the molecule tapasin. Once loaded with peptides, MHC I molecules pass through the secretory pathway en route to the cell surface. During this transit, some MHC I molecules encounter scrutiny from the tapasin homologue, TAPBPR.
TAPBPR, like tapasin, performs a "peptide editing" function that results in the preferential selection of peptides that bind with high affinity, allowing the most effective antigen presentation.
My research is focused on how MHC I molecules select peptides for presentation, and how tapasin and TAPBPR modulate this process.
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Research groups
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Research interests
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Current research
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Research projects
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Publications
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Supervision
Current PhD Students
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Teaching
I am module lead for the Research Dissertation module on the Cancer Biology and Immunology Masters (Medi6250) course.
I present immunology lectures for Master's students on the Human Biology and Systems (Medi6226) course.
I facilitate tutorials for undergraduate first year students in the Foundations of Medicine course.
I supervise undergraduates undertaking lab their research projects, as well as summer students and interns seeking working experience. I also supervise postgraduate masters students during lab research projects.
I am co-supervisor for a PhD student.
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Biography
Dr Andy van Hateren is a senior post-doctoral research fellow working with Prof Edd James (University of Southampton) and Prof Tim Elliott (University of Oxford), investigating the mechanisms of Major Histocompatibility Complex class I peptide selection, and how tapasin and TAPBPR modulate peptide selection.
Dr van Hateren runs a part of the lab in the Life Sciences building. supervising a research assistant as well as students.
Dr van Hateren also presents immunology lectures, facilitates tutorials, leads the research project module for the Cancer Biology and Immunology masters course, supervises students during research projects, and is a personal academic tutor.
Prizes
- Postdoctoral association research prize (2014)
You can update your biography section in Pure (opens in a new tab). Select your ‘Personal’ tab then ‘Edit profile’. Under the heading, and ‘Curriculum and research description’, select ‘Add profile information’. In the dropdown menu, select - ‘Biography’. Aim for no more than 400 words.
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Prizes
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