Staff

Lead researchers

Professor Jacek Brodzki

Head of School

Research interests

  • Topological data analysis
  • Applications of topology to medicine, biology, chemistry, physics, computer science
  • Noncommutative Geometry
Connect with Jacek

Email: [email protected]

Other researchers

Professor Jeremy Frey

Professor of Physical Chemistry
Connect with Jeremy

Email: [email protected]

Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 
  • Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.
Connect with Ratko

Email: [email protected]

Professor Mahesan Niranjan

ISIS Chair
Connect with Mahesan

Email: [email protected]

Professor Peter Smith BSc, PhD, MA, FRSB

Professor of Life Sciences
Connect with Peter

Email: [email protected]

Collaborating research institutes, centres and groups

Research outputs

Exactness of locally compact groups
Jacek Brodzki, Christopher Cave & Kang Li, 2017, Advances in Mathematics, 312, 209-233
DOI: 10.1016/j.aim.2017.03.020
Type: article
The periodic cyclic homology of crossed products of finite type algebras
Jacek Brodzki, Shantanu Dave & Victor Nistor, 2017, Advances in Mathematics, 306, 494-523
DOI: 10.1016/j.aim.2016.10.025
Type: article
Robust portfolio risk minimization using the graphical lasso
Tristan Millington & Mahesan Niranjan, 2017
DOI: 10.1007/978-3-319-70096-0_88
Type: conference
The local spectrum of the Dirac operator for the universal cover of SL_2(R)
Jacek Brodzki, Graham A. Niblo, Roger Plymen & Nick Wright, 2016, Journal of Functional Analysis, 270(3), 957-975
DOI: 10.1016/j.jfa.2015.10.010
Type: article
Quantifying the cumulative effect of low-penetrance genetic variants on breast cancer risk
Conor Smyth, Iva Spakulova, Owen Cotton-Barratt, Sajjad Rafiq, William Tapper, Rosanna Upstill-Goddard, John Hopper, Enes Makalic, Daniel Schmidt, Miroslav Kapuscinski, Jörg Fliege, Andrew Collins, Jacek Brodzki, Diana Eccles & Ben D. MacArthur, 2015, Molecular Genetics and Genomic Medicine, 3(3), 182-188
DOI: 10.1002/mgg3.129
Type: article