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Research project

Computational modelling to evaluate, understand and predict the placental transfer of xenobiotics as an integrated system

Staff

Lead researchers

Dr Bram Sengers

Associate Professor
Connect with Bram

Email: [email protected]

Other researchers

Professor Xunli Zhang PhD, DIC, FRSC, CChem, CEng

Professor of Bioengineering

Research interests

  • Microfluidics and Lab-on-a-Chip Technologies
  • Biomedical and Chemical Engineering
  • Nanomaterials
Connect with Xunli

Email: [email protected]

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology
Connect with Rohan

Email: [email protected]

Dr Jane Cleal PhD

Associate Professor

Research interests

  • Areas of Scientific Expertise:
  • Reproductive Cell Biology – Fundamental mechanisms of cell biology in placenta and endometrium and the impact on the intra-uterine environment, fetal development and lifelong health.Regulation of Reproductive Cell Biology – Maternal exposures and molecular regulation of cellular gene expression, phenotype and function in placenta and endometrium and the clinical translation.Disease/phenotype – Fetal growth, Obesity, Cardiometabolic programming, Subfertility, Recurrent pregnancy loss.Cellular mechanisms – Membrane transport, endocytosis, vesicular transport & signalling, gene transcription, microRNA biology, epigenetic regulation.Vitamin D - Transport, regulation, metabolism and signalling.
Connect with Jane

Email: [email protected]

Research outputs

Placental perfusion and mathematical modelling
Rohan Lewis, Jane Cleal & Bram Sengers, 2020, Placenta, 93, 43-48
DOI: 10.1016/j.placenta.2020.02.015
Type: review
Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta
Emma M Lofthouse, Christopher Torrens, Antigoni Manousopoulou, Monica Nahar, Jane K. Cleal, Ita M O'Kelly, Bram G. Sengers, Spiros D. Garbis & Rohan M Lewis, 2019, The FASEB Journal, 33(7), 8211-8220
DOI: 10.1096/fj.201900015RR
Type: article
A systems perspective on placental amino acid transport
Jane K. Cleal, Emma M. Lofthouse, Bram G. Sengers & Rohan M. Lewis, 2018, The Journal of Physiology, 596(23), 5511-5522
DOI: 10.1113/JP274883
Type: review
Estrone sulphate uptake by the microvillous membrane of placental syncytiotrophoblast is coupled to glutamate efflux
Emma M Lofthouse, Jane K Cleal, Ita M O'Kelly, Bram G Sengers & Rohan M Lewis, 2018, Biochemical and Biophysical Research Communications
DOI: 10.1016/j.bbrc.2018.10.074
Type: article