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Research project

Dr P Howarth: 'Wessex severe asthma cohort'

Staff

Other researchers

Professor Donna Davies

Research interests

  • Mechanisms of lung diseases
  • Viral-induced exacerbations of lung disease
  • Asthma
Connect with Donna

Email: [email protected]

Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 
  • Stratification of asthma into clinical phenotypes and mechanism-based endotypes: Professor Djukanovic led the discovery of biomarkers using omics technology (transcriptomics, proteomics, lipidomics, breathomics). After the first ever study of transcriptomics biomarkers in the epithelium of patients with Chronic Obstructive Pulmonary Disease (COPD), together with a colleague from Amsterdam and two colleagues from Imperial College, London, he created a large (€27 milllion) programme for severe asthma (U-BIOPRED), funded by the EU Innovative Medicines Initiative. This has resulted in more than 100 publications, providing insight into novel phenotypes and endotypes of asthma.
Connect with Ratko

Email: [email protected]

Research outputs

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life
Elizabeth R. Davies, Joanne F. Kelly, Peter H. Howarth, David Wilson, Stephen Holgate, Donna E. Davies, Jeffrey A. Whitsett & Hans Michael Haitchi, 2016, JCI Insight, 1(11), 1-16
DOI: 10.1172/jci.insight.87632
Type: article
Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1
Timothy Hinks, T. Brown, L.C. Lau, H. Rupani, Clair Barber, S. Elliott, J.A. Ward, J. Ono, S. Ohta, K. Izuhara, R. Djukanovic, R.J. Kurukulaaratchy, A. Chauhan & P. Howarth, 2016, Journal of Allergy and Clinical Immunology, 138(1), 61-75
DOI: 10.1016/j.jaci.2015.11.020
Type: article
Toll-like receptor 7 is reduced in severe asthma and linked to altered microRNA profile
2016, American Journal of Respiratory and Critical Care Medicine, 194(1), 26-37
DOI: 10.1164/rccm.201502-0280OC
Type: article
IL-1alpha mediates cellular cross-talk in the airway epithelial mesenchymal trophic unit
Alison R. Hill, Jess E. Donaldson, Cornelia Blume, Natalie Smithers, Liku Tezera, Kamran Tariq, Patrick Dennison, Hitasha Rupani, Matthew J. Edwards, Peter H. Howarth, Chris Grainge, Donna E. Davies & Emily J. Swindle, 2016, Tissue Barriers, 4(3), 1-12
DOI: 10.1080/21688370.2016.1206378
Type: article
Airway surfactant protein D deficiency in adults with severe asthma
2016, Chest, 149(5), 1165-1172
DOI: 10.1016/j.chest.2015.11.012
Type: article