Research project

Prof Tom Fleming BBSRC Pre-implantation Embryos

Lead researchers:

Emeritus Professor Thomas Fleming
Other researchers:

Emeritus Professor Mark Hanson,

Professor Rohan Lewis
Research funder:

Biotechnology & Biological Sciences Research Council
Status:

Not active

Staff

Lead researchers

Emeritus Professor Thomas Fleming

Connect with Thomas

Email: [email protected]

Other researchers

Emeritus Professor Mark Hanson

Connect with Mark

Email: [email protected]

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology

Connect with Rohan

Email: [email protected]

Research outputs

Mouse maternal protein restriction during preimplantation alone permanently alters brain neuron proportion and adult short-term memory

Joanna, Mary Gould, Phoebe J. Smith, Chris J. Airey, Emily J. Mort, Lauren E Airey, Frazer DM Warricker, Jennifer, Elizabeth Pearson-Farr, Eleanor C Weston, Philippa JW Gould, Oliver G Semmence, Katie L. Restall, J.A Watts, Patrick C McHugh, Stephanie J Smith, Jennifer M. Dewing, Thomas P. Fleming & Sandrine Willaime-Morawek, 2018, Proceedings of National Academy of Sciences of the United States of America, 115(13), E7398-E7407

DOI: 10.1073/pnas.1721876115

Type: article

Origins of lifetime health around the time of conception

T.P. Fleming, A. Watkins, M.A. Velazquez, J. C. Mathers, A.M. Prentice, J. Stephenson, Mary Barker, R. Saffery, Chittaranjan S. Yajnik, Judith Eckert, Mark Hanson, T. Forrester, Peter D. Gluckman & Keith Godfrey, 2018, The Lancet, 391(10132), 1842–1852

DOI: 10.1016/S0140-6736(18)30312-X

Type: article

Insulin and branched-chain amino acid depletion during mouse preimplantation embryo culture programmes body weight gain and raised blood pressure during early postnatal life

Miguel A. Velazquez, Bhavwanti Sheth, Stephanie J. Smith, Judith J. Eckert, Clive Osmond & Tom P. Fleming, 2018, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1864(2), 590-600

DOI: 10.1016/j.bbadis.2017.11.020

Type: article

Advanced maternal age causes adverse programming of mouse blastocysts leading to altered growth and impaired cardiometabolic health in post-natal life

M.A. Velazquez, C.G.C. Smith, N.R. Smyth, C. Osmond & Thomas Fleming, 2016, Human Reproduction, 31(9), 1970-80

DOI: 10.1093/humrep/dew177

Type: article

Regulation of ribosomal RNA expression across the lifespan is fine-tuned by maternal diet before implantation

Oleg Denisenko, Emma S. Lucas, Congshan Sun, Adam J. Watkins, Daniel Mar, Karol Bomsztyk & Tom P. Fleming, 2016, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 1859(7), 906-913

DOI: 10.1016/j.bbagrm.2016.04.001

Type: article