Project overview
This interdisciplinary project investigated how amino acids cross the placenta to feed the fetus while it is growing in the womb. We combined laboratory experiments with mathematical modelling to provide new insight into how the placentas work and how membrane transporters carry amino acids across membranes. A key outcome of this work was the demonstration that simply increasing the levels of amino acids in the mothers blood will not effectively increase supply to the fetus.
Staff
Lead researchers
Other researchers
Research outputs
Emma M Lofthouse, Jane K Cleal, Ita M O'Kelly, Bram G Sengers & Rohan M Lewis,
2018, Biochemical and Biophysical Research Communications
Type: article
N. Panitchob, K.L. Widdows, I.P. Crocker, E.D. Johnstone, C.P. Please, C.P. Sibley, J.D. Glazier, R. Lewis & B. Sengers,
2016, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1-31
Type: article
E.M. Lofthouse, S. Perazzolo, S. Brooks, I.P. Crocker, J.D. Glazier, E.D. Johnstone, N. Panitchob, C.P. Sibley, K.L. Widdows, B.G. Sengers & R.M. Lewis,
2015, American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 1-28
Type: article
Emma Lofthouse, S. Brooks, J. Cleal, M. Hanson, K. Poore, Ita O'Kelly & R. Lewis,
2015, The Journal of Physiology, 593(20), 4549-4559
DOI: 10.1113/JP270743
Type: article
S. Perazzolo, B. Hirschmugl, C. Wadsack, G. Desoye, R Lewis & B. G. Sengers,
2015
Type: conference