About
The Genomic Informatic group, led by Dr Tapper, specialises in identifying novel germline and somatic variants which influence the risk of developing disease and clinical outcomes and how this knowledge can be translated into improved diagnosis, risk prediction and personalised treatment. The group uses a wide range of bioinformatic and statistical techniques to analyse large-scale genetic datasets including next generation sequencing (NGS), genome-wide association studies (GWAS), polygenic risk scores (PRS), Mendelian randomisation, network analysis, data integration and machine learning.
Research
Research groups
Current research
- Long term follow-up of the POSH cohort to determine disease risks for distant, locoregional and new primary disease in young-onset breast cancer patients with known BRCA1/2 mutation status
- Genome-wide association study of outcome after aneurysmal subarachnoid haemorrhage
- Developing a polygenic risk score for pancreatic cancer
- Utilising multiomic data to understand therapy resistance in paediatric rhabdomyosarcomas
- Utilising patient omic information to identify target mechanisms of resistance in sarcomas
- Genomics of food allergy and food allergen sensitisation
Research projects
Active projects
Sponsor: Sarcoma UK
Researchers:
Completed projects
Sponsor: Breast Cancer Now
Researchers:
Sponsor: Blood Cancer UK
Researchers:
Sponsor: Sarcoma UK
Researchers:
Sponsor: Breast Cancer Research Trust
Researchers:
Sponsor: Blood Cancer UK
Sponsor: Breast Cancer Now
Publications
128 publications
Page 8 of 13
Rosanna Upstill-Goddard, Diana Eccles, Sarah Ennis, Sajjad Rafiq, William Tapper, Joerg Fliege & Andrew Collins,
2013, PLoS ONE, 8(7), e68606
Type: article
K. Christodoulou, A.E. Wiskin, J. Gibson, W. Tapper, C. Willis, N.A. Afzal, R. Upstill-Goddard, J.W. Holloway, M.A. Simpson, R.M. Beattie, A. Collins & S. Ennis,
2013, Gut, 62(7), 977-984
Type: article
Montserrat Garcia-Closas, Fergus J. Couch, Sara Lindstrom, Kyriaki Michailidou, Marjanka K. Schmidt, Mark N. Brook, Nick Orr, Suhn Kyong Rhie, Elio Riboli, Heather S. Feigelson, Loic Le Marchand, Julie E. Buring, Diana Eccles, Penelope Miron, Peter A. Fasching, Hiltrud Brauch, Jenny Chang-Claude, Jane Carpenter, Andrew K. Godwin, Heli Nevanlinna, Graham G. Giles, Angela Cox, John L. Hopper, Manjeet K. Bolla, Qin Wang, Joe Dennis, Ed Dicks, Will J. Howat, Nils Schoof, Stig E. Bojesen, Diether Lambrechts, Annegien Broeks, Irene L. Andrulis, Pascal Guénel, Barbara Burwinkel, Elinor J. Sawyer, Antoinette Hollestelle, Olivia Fletcher, Robert Winqvist, Hermann Brenner, Arto Mannermaa, Ute Hamann, Alfons Meindl, Annika Lindblom, Wei Zheng, Peter Devillee, Mark S. Goldberg, Jan Lubinski, Vessela Kristensen, Anthony Swerdlow, Hoda Anton-Culver, Thilo Dörk, Kenneth Muir, Keitaro Matsuo, Anna H. Wu, Paolo Radice, Soo Hwang Teo, Xiao-Ou Shu, William Blot, Daehee Kang, Mikael Hartman, Suleeporn Sangrajrang, Chen-Yang Shen, Melissa C. Southey, Daniel J. Park, Fleur Hammet, Jennifer Stone, Laura J. Van't Veer, Emiel J. Rutgers, Artitaya Lophatananon, Sarah Stewart-Brown, Pornthep Siriwanarangsan, Julian Peto, Michael G. Schrauder, Arif B. Ekici, Matthias W. Beckmann, Isabel dos Santos Silva, Nichola Johnson, Helen Warren, Ian Tomlinson, Michael J Kerin, Nicola Miller, Federick Marme, Andreas Schneeweiss, Christof Sohn, Therese Truong, Pierre Laurent-Puig, Pierre Kerbrat, Børge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Roger L. Milne, Jose Ignacio Arias Perez, Primitiva Menéndez, Heiko Müller, Volker Arndt, Christa Stegmaier, Peter Lichtner, Magdalena Lochmann, Christina Justenhoven, Yon-Dschun Ko, Taru A. Muranen, Kristiina Aittomäki, Carl Blomqvist, Dario Greco, Tuomas Heikkinen, Hidemi Ito, Hiroji Iwata, Yasushi Yatabe, Natalia N. Antonenkova, Sara Margolin, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Rosemary Balleine, Chiu-Chen Tseng, David Van Den Berg, Daniel O. Stram, Patrick Neven, Anne-Sophie Dieudonné, Karin Leunen, Anja Rudolph, Stefan Nickels, Dieter Flesch-Janys, Paolo Peterlongo, Bernard Peissel, Loris Bernard, Janet E. Olson, Xianshu Wang, Kristen Stevens, Gianluca Severi, Laura Baglietto, Catriona McLean, Gerhard A. Coetzee, Ye Feng, Brian E. Henderson, Fredrick Schumacher, Natalia V. Bogdanova, France Labrèche, Martine Dumont, Cheng Har Yip, Nur Aishah Mohd Taib, Ching-Yu Cheng, Martha Shrubsole, Jirong Long, Katri Pylkäs, Arja Jukkola-Vuorinen, Saila Kauppila, Julia A. Knight, Gord Glendon, Anna Marie Mulligan, Robertus A. E. M. Tollenaar, Caroline M. Seynaeve, Mieke Kriege, Maartje J. Hooning, Ans M. W. van den Ouweland, Carolien H. M. van Deurzen, Wei Lu, Yu-Tang Gao, Hui Cai, Sabapathy P. Balasubramanian, Simon S. Cross, Malcolm W. R. Reed, Lisa Signorello, Qiuyin Cai, Mitul Shah, Hui Miao, Ching Wan Chan, Kee Seng Chia, Anna Jakubowska, Katarzyna Jaworska, Katarzyna Durda, Chia-Ni Hsiung, Pei-Ei Wu, Jyh-Cherng Yu, Alan Ashworth, Michael Jones, Daniel C. Tessier, Anna González-Neira, Guillermo Pita, M. Rosario Alonso, Daniel Vincent, Francois Bacot, Christine B. Ambrosone, Elisa V. Bandera, Esther M. John, Gary K. Chen, Jennifer J. Hu, Jorge L. Rodriguez-Gil, Leslie Bernstein, Michael F. Press, Regina G. Ziegler, Robert M. Millikan, Sandra L. Deming-Halverson, Sarah Nyante, Sue A. Ingles, Quinten Waisfisz, Helen Tsimiklis, Enes Makalic, Daniel Schmidt, Minh Bui, Lorna Gibson, Bertram Müller-Myhsok, Rita K. Schmutzler, Rebecca Hein, Norbert Dahmen, Lars Beckmann, Kirsimari Aaltonen, Kamila Czene, Astrid Irwanto, Jianjun Liu, Clare Turnbull, Nazneen Rahman, Hanne Meijers-Heijboer, Andre G. Uitterlinden, Fernando Rivadeneira, Curtis Olswold, Susan Slager, Robert Pilarski, Foluso Ademuyiwa, Irene Konstantopoulou, Nicholas G. Martin, Grant W. Montgomery, Dennis J. Slamon, Claudia Rauh, Michael P. Lux, Sebastian M. Jud, Thomas Bruning, JoEllen Weaver, Priyanka Sharma, Harsh Pathak, Will Tapper, Sue Gerty, Lorraine Durcan, Dimitrios Trichopoulos, Rosario Tumino, Petra H. Peeters, Rudolf Kaaks, Daniele Campa, Federico Canzian, Elisabete Weiderpass, Mattias Johansson, Kay-Tee Khaw, Ruth Travis, Françoise Clavel-Chapelon, Laurence N. Kolonel, Constance Chen, Andy Beck, Susan E. Hankinson, Christine D. Berg, Robert N. Hoover, Jolanta Lissowska, Jonine D. Figueroa, Daniel I. Chasman, Mia M. Gaudet, W. Ryan Diver, Walter C. Willett, David J. Hunter, Jacques Simard, Javier Benitez, Alison M. Dunning, Mark E. Sherman, Georgia Chenevix-Trench, Stephen J. Chanock, Per Hall, Paul D. P. Pharoah, Celine Vachon, Douglas F. Easton, Christopher A. Haiman & Peter Kraft,
2013, Nature Genetics, 45(4), 392-398
DOI: 10.1038/ng.2561
Type: article
Sajjad Rafiq, William Tapper, Andrew Collins, Sofia Khan, Ionnis Politopoulos, Sue Gerty, Carl Blomqvist, Fergus J. Couch, Heli Nevanlinna, Jianjun Liu & Diana Eccles,
2013, Cancer Research, 73(6), 1883-1891
Type: article
Jane Gibson, William Tapper, Sarah Ennis & Andrew Collins,
2013, Human Genetics, 132(2), 233-243
Type: article
Rocco Piazza, Simona Valletta, Nils Winkelmann, Sara Redaelli, Roberta Spinelli, Alessandra Pirola, Laura Antolini, Luca Mologni, Carla Donadoni, Elli Papaemmanuil, Susanne Schnittger, Dong-Wook Kim, Jacqueline Boultwood, Fabio Rossi, Giuseppe Gaipa, Greta P. De Martini, Paola Francia di Celle, Hyun Gyung Jang, Valeria Fantin, Graham R. Bignell, Vera Magistroni, Torsten Haferlach, Enrico Maria Pogliani, Peter J. Campbell, Andrew J Chase, William J. Tapper, Nicholas C. P. Cross & Carlo Gambacorti-Passerini,
2013, Nature Genetics, 45(1), 18-24
DOI: 10.1038/ng.2495
Type: article
K. Moore, G. Thomas, S. Duffy, J. Warwick, R. Gabe, P. Chou, I. Ellis, A. Green, S. Haider, K. Brouilette, A. Saha, S. Vallath, R. Bowen, C. Chelala, D. Eccles, W. Tapper, A. Thompson, P. Quinlan, L. Jordan, C. Gillett, A. Brentall, S. Violette, P. Weinreb, J. Kendrew, S. Barry, I. Hart, L. Jones & J. Marshall,
2013, JNCI Journal of the National Cancer Institute
Type: article
A. Siddiq, F.J. Couch, G.K. Chen, S. Lindstrom, D. Eccles, R.C. Millikan, K. Michailidou, D.O. Stram, L. Beckmann, S.K. Rhie, C.B. Ambrosone, K. Aittomaki, P. Amiano, C. Apicella, L. Baglietto, E.V. Bandera, M.W. Beckmann, C.D. Berg, L. Bernstein, C. Blomqvist, H. Brauch, L. Brinton, Q.M. Bui, J.E. Buring, S.S. Buys, D. Campa, J.E. Carpenter, D.I. Chasman, J. Chang-Claude, C. Chen, F. Clavel-Chapelon, A. Cox, S.S. Cross, K. Czene, S.L. Deming, R.B. Diasio, W.R. Diver, A.M. Dunning, L. Durcan, A.B. Ekici, P.A. Fasching, H.S. Feigelson, L. Fejerman, J.D. Figueroa, O. Fletcher, D. Flesch-Janys, M.M. Gaudet, S.M. Gerty, J.L. Rodriguez-Gil, G.G. Giles, C.H. van Gils, A.K. Godwin, N. Graham, D. Greco, P. Hall, S.E. Hankinson, A. Hartmann, R. Hein, J. Heinz, R.N. Hoover, J.L. Hopper, J.J. Hu, S. Huntsman, S.A. Ingles, A. Irwanto, C. Isaacs, K.B. Jacobs, E.M. John, C. Justenhoven, R. Kaaks, L.N. Kolonel, G.A. Coetzee, M. Lathrop, L. Le Marchand, A.M. Lee, I.-M. Lee, T. Lesnick, P. Lichtner, J. Liu, E. Lund, E. Makalic, N.G. Martin, C.A. McLean, H. Meijers-Heijboer, A. Meindl, P. Miron, K.R. Monroe, G.W. Montgomery, B. Muller-Myhsok, S. Nickels, S.J. Nyante, C. Olswold, K. Overvad, D. Palli, D.J. Park, J.R. Palmer, H. Pathak, J. Peto, P. Pharoah, N. Rahman, F. Rivadeneira, D.F. Schmidt, R.K. Schmutzler, S. Slager, M.C. Southey, K.N. Stevens, H.-P. Sinn, M.F. Press, E. Ross, E. Riboli, P.M. Ridker, F.R. Schumacher, G. Severi, I. dos Santos Silva, J. Stone, M. Sund, W.J. Tapper, M.J. Thun, R.C. Travis, C. Turnbull, A.G. Uitterlinden, Q. Waisfisz, X. Wang, Z. Wang, J. Weaver, R. Schulz-Wendtland, L.R. Wilkens, D. Van Den Berg, W. Zheng, R.G. Ziegler, E. Ziv, H. Nevanlinna, D.F. Easton, D.J. Hunter, B.E. Henderson, S.J. Chanock, M. Garcia-Closas, P. Kraft, C.A. Haiman & C.M. Vachon,
2012, Human Molecular Genetics, 21(24), 5373-5384
DOI: 10.1093/hmg/dds381
Type: article
K.D. Boyd, F.M. Ross, L. Chiecchio, G.P. Dagrada, Z.J. Konn, W.J. Tapper, B.A. Walker, C.P. Wardell, W.M. Gregory, A.J. Szubert, S.E. Bell, J.A. Child, G.H. Jackson, F.E. Davies & G.J. Morgan,
2012, Leukemia, 26(2), 349-355
DOI: 10.1038/leu.2011.204
Type: article
Maya Ghoussaini, Olivia Fletcher, Kyriaki Michailidou, Clare Turnbull, Marjanka K. Schmidt, Ed Dicks, Joe Dennis, Qin Wang, Manjeet K. Humphreys, Craig Luccarini, Caroline Baynes, Don Conroy, Melanie Maranian, Shahana Ahmed, Kristy Driver, Nichola Johnson, Nicholas Orr, Isabel dos Santos Silva, Quinten Waisfisz, Hanne Meijers-Heijboer, Andre G. Uitterlinden, Fernando Rivadeneira, Per Hall, Kamila Czene, Astrid Irwanto, Jianjun Liu, Heli Nevanlinna, Kristiina Aittomäki, Carl Blomqvist, Alfons Meindl, Rita K. Schmutzler, Bertram Müller-Myhsok, Peter Lichtner, Jenny Chang-Claude, Rebecca Hein, Stefan Nickels, Dieter Flesch-Janys, Helen Tsimiklis, Enes Makalic, Daniel Schmidt, Minh Bui, John L. Hopper, Carmel Apicella, Daniel J. Park, Melissa Southey, David J. Hunter, Stephen J. Chanock, Annegien Broeks, Senno Verhoef, Frans B.L. Hogervorst, Peter A. Fasching, Michael P. Lux, Matthias W. Beckmann, Arif B. Ekici, Elinor Sawyer, Ian Tomlinson, Michael Kerin, Frederik Marme, Andreas Schneeweiss, Christof Sohn, Barbara Burwinkel, Pascal Guénel, Thérèse Truong, Emilie Cordina-Duverger, Florence Menegaux, Stig E. Bojesen, Børge G. Nordestgaard, Sune F. Nielsen, Henrik Flyger, Roger L. Milne, M. Rosario Alonso, Anna González-Neira, Javier Benítez, Hoda Anton-Culver, Argyrios Ziogas, Leslie Bernstein, Christina Clarke Dur, Hermann Brenner, Heiko Müller, Volker Arndt, Christa Stegmaier, Christina Justenhoven, Hiltrud Brauch, Thomas Brüning, Shan Wang-Gohrke, Ursula Eilber, Thilo Dörk, Peter Schürmann, Michael Bremer, Peter Hillemanns, Natalia V. Bogdanova, Natalia N. Antonenkova, Yuri I. Rogov, Johann H. Karstens, Marina Bermisheva, Darya Prokofieva, Elza Khusnutdinova, Annika Lindblom, Sara Margolin, Arto Mannermaa, Vesa Kataja, Veli-Matti Kosma, Jaana M. Hartikainen, Diether Lambrechts, Betul T. Yesilyurt, Giuseppe Floris, Karin Leunen, Siranoush Manoukian, Bernardo Bonanni, Stefano Fortuzzi, Paolo Peterlongo, Fergus J. Couch, Xianshu Wang, Kristen Stevens, Adam Lee, Graham G. Giles, Laura Baglietto, Gianluca Severi, Catriona McLean, Grethe Grenaker Alnæs, Vessela Kristensen, Anne-Lise Børrensen-Dale, Esther M. John, Alexander Miron, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Saila Kauppila, Irene L. Andrulis, Gord Glendon, Anna Marie Mulligan, Peter Devilee, Christie J. van Asperen, Rob A.E.M. Tollenaar, Caroline Seynaeve, Jonine D. Figueroa, Montserrat Garcia-Closas, Louise Brinton, Jolanta Lissowska, Maartje J. Hooning, Antoinette Hollestelle, Rogier A. Oldenburg, Ans M.W. van den Ouweland, Angela Cox, Malcolm W.R. Reed, Mitul Shah, Ania Jakubowska, Jan Lubinski, Katarzyna Jaworska, Katarzyna Durda, Michael Jones, Minouk Schoemaker, Alan Ashworth, Anthony Swerdlow, Jonathan Beesley, Xiaoqing Chen, Kenneth R. Muir, Artitaya Lophatananon, Suthee Rattanamongkongul, Arkom Chaiwerawattana, Daehee Kang, Keun-Young Yoo, Dong-Young Noh, Chen-Yang Shen, Jyh-Cherng Yu, Pei-Ei Wu, Chia-Ni Hsiung, Annie Perkins, Ruth Swann, Louiza Velentzis, Diana M. Eccles, Will J. Tapper, Susan M. Gerty, Nikki J. Graham, Bruce A.J. Ponder, Georgia Chenevix-Trench, Paul D.P. Pharoah, Mark Lathrop, Alison M. Dunning, Nazneen Rahman, Julian Peto & Douglas F. Easton,
2012, Nature Genetics, 44(3), 312-318
DOI: 10.1038/ng.1049
Type: article
Teaching
Dr Tapper is the Module lead for 'Genomic Technologies and Basic Informatics' and 'Genomic Informatics' for the MSc in Genomics. He delivers lectures for several modules, supervises MSc, PhD and iPhD students and marks their research projects.
Dr Tapper contributes to undergraduate teaching of Medicine (BM5) via his role as the Head of Feild for Genetics and as a Personal Academic tutor. He also supervises and marks third year student projects.