About
The Genomic Informatic group, led by Dr Tapper, specialises in identifying novel germline and somatic variants which influence the risk of developing disease and clinical outcomes and how this knowledge can be translated into improved diagnosis, risk prediction and personalised treatment. The group uses a wide range of bioinformatic and statistical techniques to analyse large-scale genetic datasets including next generation sequencing (NGS), genome-wide association studies (GWAS), polygenic risk scores (PRS), Mendelian randomisation, network analysis, data integration and machine learning.
Research
Research groups
Current research
- Long term follow-up of the POSH cohort to determine disease risks for distant, locoregional and new primary disease in young-onset breast cancer patients with known BRCA1/2 mutation status
- Genome-wide association study of outcome after aneurysmal subarachnoid haemorrhage
- Developing a polygenic risk score for pancreatic cancer
- Utilising multiomic data to understand therapy resistance in paediatric rhabdomyosarcomas
- Utilising patient omic information to identify target mechanisms of resistance in sarcomas
- Genomics of food allergy and food allergen sensitisation
Research projects
Active projects
Sponsor: Sarcoma UK
Researchers:
Completed projects
Sponsor: Breast Cancer Now
Researchers:
Sponsor: Blood Cancer UK
Researchers:
Sponsor: Sarcoma UK
Researchers:
Sponsor: Breast Cancer Research Trust
Researchers:
Sponsor: Blood Cancer UK
Sponsor: Breast Cancer Now
Publications
128 publications
Page 10 of 13
Antonis C. Antoniou, Xianshu Wang, Zachary S. Fredericksen, Lesley McGuffog, Robert Tarrell, Olga M. Sinilnikova, Sue Healey, Jonathan Morrison, Christiana Kartsonaki, Timothy Lesnick, Maya Ghoussaini, Daniel Barrowdale, Susan Peock, Margaret Cook, Clare Oliver, Debra Frost, Diana Eccles, D. Gareth Evans, Ros Eeles, Louise Izatt, Carol Chu, Fiona Douglas, Joan Paterson, Dominique Stoppa-Lyonnet, Claude Houdayer, Sylvie Mazoyer, Sophie Giraud, Christine Lasset, Audrey Remenieras, Olivier Caron, Agnès Hardouin, Pascaline Berthet, Frans B. L. Hogervorst, Matti A. Rookus, Agnes Jager, Ans van den Ouweland, Nicoline Hoogerbrugge, Rob B. van der Luijt, Hanne Meijers-Heijboer, Encarna B. Gómez García, Peter Devilee, Maaike P. G. Vreeswijk, Jan Lubinski, Anna Jakubowska, Jacek Gronwald, Tomasz Huzarski, Tomasz Byrski, Bohdan Górski, Cezary Cybulski, Amanda B. Spurdle, Helene Holland, David E. Goldgar, Esther M. John, John L. Hopper, Melissa Southey, Saundra S. Buys, Mary B. Daly, Mary-Beth Terry, Rita K. Schmutzler, Barbara Wappenschmidt, Christoph Engel, Alfons Meindl, Sabine Preisler-Adams, Norbert Arnold, Dieter Niederacher, Christian Sutter, Susan M. Domchek, Katherine L. Nathanson, Timothy Rebbeck, Joanne L. Blum, Marion Piedmonte, Gustavo C. Rodriguez, Katie Wakeley, John F. Boggess, Jack Basil, Stephanie V. Blank, Eitan Friedman, Bella Kaufman, Yael Laitman, Roni Milgrom, Irene L. Andrulis, Gord Glendon, Hilmi Ozcelik, Tomas Kirchhoff, Joseph Vijai, Mia M. Gaudet, David Altshuler, Candace Guiducci, Niklas Loman, Katja Harbst, Johanna Rantala, Hans Ehrencrona, Anne-Marie Gerdes, Mads Thomassen, Lone Sunde, Paolo Peterlongo, Siranoush Manoukian, Bernardo Bonanni, Alessandra Viel, Paolo Radice, Trinidad Caldes, Miguel de la Hoya, Christian F Singer, Anneliese Fink-Retter, Mark H. Greene, Phuong L. Mai, Jennifer T. Loud, Lucia Guidugli, Noralane M. Lindor, Thomas V. O. Hansen, Finn C. Nielsen, Ignacio Blanco, Conxi Lazaro, Judy Garber, Susan J. Ramus, Simon A. Gayther, Catherine Phelan, Stephen Narod, Csilla I. Szabo, Javier Benitez, Ana Osorio, Heli Nevanlinna, Tuomas Heikkinen, Maria A. Caligo, Mary S. Beattie, Ute Hamann, Andrew K. Godwin, Marco Montagna, Cinzia Casella, Susan L. Neuhausen, Beth Y. Karlan, Nadine Tung, Amanda E. Toland, Jeffrey Weitzel, Olofunmilayo Olopade, Jacques Simard, Penny Soucy, Wendy S. Rubinstein, Adalgeir Arason, Gad Rennert, Nicholas G. Martin, Grant W. Montgomery, Jenny Chang-Claude, Dieter Flesch-Janys, Hiltrud Brauch, Gianluca Severi, Laura Baglietto, Angela Cox, Simon S Cross, Penelope Miron, Sue M. Gerty, William Tapper, Drakoulis Yannoukakos, George Fountzilas, Peter A. Fasching, Matthias W. Beckmann, Isabel dos Santos Silva, Julian Peto, Diether Lambrechts, Robert Paridaens, Thomas Rüdiger, Asta Försti, Robert Winqvist, Katri Pylkäs, Robert B. Diasio, Adam M. Lee, Jeanette Eckel-Passow, Celine Vachon, Fiona Blows, Kristy Driver, Alison Dunning, Paul P. D. Pharoah, Kenneth Offit, V Shane Pankratz, Hakon Hakonarson, Georgia Chenevix-Trench, Douglas F. Easton & Fergus J. Couch,
2010, Nature Genetics, 42(10), 885-892
DOI: 10.1038/ng.669
Type: article
Amy V. Jones, Peter J. Campbell, Philip A. Beer, Sussane Schnittger, Alessandro M. Vannucchi, Katerina Zoi, Melanie J. Percy, Mary Frances McMullin, Linda M. Scott, William Tapper, Richard T. Silver, D. Oscier, Claire N. Harrison, Harald Grallert, Aliaksei Kisialiou, Paul Strike, Andrew J. Chase, Anthony R. Green & Nicholas C.P. Cross,
2010, Blood, 115(22), 4517-4523
Type: article
Clare Turnbull, Shahana Ahmed, Jonathan Morrison, David Pernet, Anthony Renwick, Mel Maranian, Sheila Seal, Maya Ghoussaini, Sarah Hines, Catherine S Healey, Deborah Hughes, Margaret Warren-Perry, William Tapper, Diana Eccles, D Gareth Evans, Maartje Hooning, Mieke Schutte, Ans van den Ouweland, Richard Houlston, Gillian Ross, Cordelia Langford, Paul D P Pharoah, Michael R Stratton, Alison M Dunning, Nazneen Rahman & Douglas F Easton,
2010, Nature Genetics, 42(6), 504-507
DOI: 10.1038/ng.586
Type: article
Diana Eccles & William Tapper,
2010, Cancer Research, 155, 15-32
Type: article
Rodney D. Gilbert, Claire L.S. Turner, Jane Gibson, Paul S. Bass, Mushfequr R. Haq, Esta Cross, David J. Bunyan, Andrew R. Collins, William J. Tapper, Juliet C. Needell, Beverley Dell, Newton E. Morton, I. Karen Temple & David O. Robinson,
2009, Kidney International, 75(4), 415-419
DOI: 10.1038/ki.2008.573
Type: article
William Tapper, Victoria Hammond, Sue Gerty, Sarah Ennis, Peter Simmonds, Andrew Collins & Diana Eccles,
2008, Breast Cancer Research, 10(6), R108
DOI: 10.1186/bcr2213
Type: article
William Tapper, Jane Gibson, Newton E. Morton & Andrew Collins,
2008, Human Heredity, 66(3), 157-169
DOI: 10.1159/000126050
Type: article
Jane Gibson, William Tapper, David Cox, Weihua Zhang, Arne Pfeufer, Christian Gieger, H.-Erich Wichmann, Stefan Kaab, Andrew R. Collins, Thomas Meitinger & Newton Morton,
2008, Proceedings of the National Academy of Sciences of the United States of America, 105(7), 2592-2597
Type: article
William Tapper,
2008
Type: bookChapter
Teaching
Dr Tapper is the Module lead for 'Genomic Technologies and Basic Informatics' and 'Genomic Informatics' for the MSc in Genomics. He delivers lectures for several modules, supervises MSc, PhD and iPhD students and marks their research projects.
Dr Tapper contributes to undergraduate teaching of Medicine (BM5) via his role as the Head of Feild for Genetics and as a Personal Academic tutor. He also supervises and marks third year student projects.