About
The Genomic Informatic group, led by Dr Tapper, specialises in identifying novel germline and somatic variants which influence the risk of developing disease and clinical outcomes and how this knowledge can be translated into improved diagnosis, risk prediction and personalised treatment. The group uses a wide range of bioinformatic and statistical techniques to analyse large-scale genetic datasets including next generation sequencing (NGS), genome-wide association studies (GWAS), polygenic risk scores (PRS), Mendelian randomisation, network analysis, data integration and machine learning.
Research
Research groups
Current research
- Long term follow-up of the POSH cohort to determine disease risks for distant, locoregional and new primary disease in young-onset breast cancer patients with known BRCA1/2 mutation status
- Genome-wide association study of outcome after aneurysmal subarachnoid haemorrhage
- Developing a polygenic risk score for pancreatic cancer
- Utilising multiomic data to understand therapy resistance in paediatric rhabdomyosarcomas
- Utilising patient omic information to identify target mechanisms of resistance in sarcomas
- Genomics of food allergy and food allergen sensitisation
Research projects
Active projects
Sponsor: Sarcoma UK
Researchers:
Completed projects
Sponsor: Breast Cancer Now
Researchers:
Sponsor: Blood Cancer UK
Researchers:
Sponsor: Sarcoma UK
Researchers:
Sponsor: Breast Cancer Research Trust
Researchers:
Sponsor: Blood Cancer UK
Sponsor: Breast Cancer Now
Publications
128 publications
Page 9 of 13
Kevin D. Boyd, Fiona M. Ross, Brian A. Walker, Christopher P. Wardell, William J. Tapper, Laura Chiecchio, Gian Paolo Dagrada, Zoe J. Konn, Walter M. Gregory, Graham H. Jackson, J. Anthony Child, Faith E. Davies & Gareth J. Morgan,
2011, Clinical Cancer Research, 17(24), 7776-7784
Type: article
Christopher A. Haiman, Gary K. Chen, Celine M. Vachon, Federico Canzian, Alison Dunning, Robert C. Millikan, Xianshu Wang, Foluso Ademuyiwa, Shahana Ahmed, Christine B. Ambrosone, Laura Baglietto, Rosemary Balleine, Elisa V. Bandera, Matthias W. Beckmann, Christine D. Berg, Leslie Bernstein, Carl Blomqvist, William J. Blot, Hiltrud Brauch, Julie E. Buring, Lisa A. Carey, Jane E. Carpenter, Jenny Chang-Claude, Stephen J. Chanock, Daniel I. Chasman, Christine L. Clarke, Angela Cox, Simon S. Cross, Sandra L. Deming, Robert B. Diasio, Athanasios M. Dimopoulos, W. Ryan Driver, Thomas Dünnebier, Lorraine Durcan, Diana Eccles, Christopher K. Edlund, Arif B. Ekici, Peter A. Fasching, Heather S. Feigelson, Dieter Flesch-Janys, Florentia Fostira, Asta Försti, George Fountzilas, Susan M. Gerty, Graham G. Giles, Andrew K. Godwin, Paul Goodfellow, Nikki Graham, Dario Greco, Ute Hamann, Susan E. Hankinson, Arndt Hartmann, Rebecca Hein, Judith Heinz, Andrea Holbrook, Robert N. Hoover, Jennifer J. Hu, David J. Hunter, Sue A. Ingles, Astrid Irwanto, Jennifer Ivanovich, Esther M. John, Nicola Johnson, Arja Jukkola-Vuorinen, Rudolf Kaaks, Yon-Dschun Ko, Laurence N. Kolonel, Irene Konstantopoulou, Veli-Matti Kosma, Swati Kulkarni, Diether Lambrechts, Adam M. Lee, Loïc Le Marchand, Timothy Lesnick, Jianjun Liu, Sara Lindstrom, Arto Mannermaa, Sara Margolin, Nicholas G. Martin, Penelope Miron, Grant W. Montgomery, Heli Nevanlinna, Stephan Nickels, Sarah Nyante, Curtis Olswold, Julie Palmer, Harsh Pathak, Dimitrios Pectasides, Charles M. Perou, Julian Peto, Paul D.P. Pharoah, Loreall C. Pooler, Michael F. Press, Katri Pylkäs, Timothy R. Rebbeck, Jorge L. Rodriguez-Gil, Lynn Rosenberg, Eric Ross, Thomas Rüdiger, Isabel dos Santos Silva, Elinor Sawyer, Marjanka K. Schmidt, Rüdiger Schulz-Wendtland, Fredrick Schumacher, Gianluca Severi, Xin Sheng, Lisa B. Signorello, Hans-Peter Sinn, Kristen N. Stevens, Melissa C. Southey, William J. Tapper, Ian Tomlinson, Frans B.L. Hogervorst, Els Wauters, JoEllen Weaver, Hans Wildiers, Robert Winqvist, David Van Den Berg, Peggy Wan, Lucy Y. Xia, Drakoulis Yannoukakos, Wei Zheng, Regina G. Ziegler, Afshan Siddiq, Susan L. Slager, Daniel O. Stram, Douglas Easton, Peter Kraft, Brian E. Henderson & Fergus J. Couch,
2011, Nature Genetics, 43(12), 1210-1214
DOI: 10.1038/ng.985
Type: article
Kristen N. Stevens, Celine M. Vachon, Adam M. Lee, Susan Slager, Timothy Lesnick, Curtis Olswold, Peter A. Fasching, Penelope Miron, Diana Eccles, Jane E. Carpenter, Andrew K. Godwin, Christine Ambrosone, Robert Winqvist, Hiltrud Brauch, Marjanka K. Schmidt, Angela Cox, Simon S. Cross, Elinor Sawyer, Arndt Hartmann, Matthias W. Beckmann, Rüdiger Schulz-Wendtland, Arif B. Ekici, William J. Tapper, Susan M. Gerty, Lorraine Durcan, Nikki J. Graham, Rebecca Hein, Stephan Nickels, Dieter Flesch-Janys, Judith Heinz, Hans-Peter Sinn, Irene Konstantopoulou, Florentia Fostira, Dimitrios Pectasides, Athanasios M. Dimopoulos, George Fountzilas, Christine L. Clarke, Rosemary Balleine, Janet E. Olson, Zachary Fredericksen, Robert B. Diasio, Harsh Pathak, Eric Ross, JoEllen Weaver, Thomas Rüdiger, Asta Forsti, Thomas Dünnebier, Foluso Ademuyiwa, Swati Kulkarni, Katri Pylkäs, Arja Jukkola-Vuorinen, Yon-Dschun Ko, Erik Van Limbergen, Hilde Janssen, Julian Peto, Olivia Fletcher, Graham G. Giles, Laura Baglietto, Senno Verhoef, Ian Tomlinson, Veli-Matti Kosma, Jonathan Beesley, Dario Greco, Carl Blomqvist, Astrid Irwanto, Jianjun Liu, Fiona M. Blows, Sarah-Jane Dawson, Sara Margolin, Arto Mannermaa, Nicholas G. Martin, Grant W. Montgomery, Diether Lambrechts, Isabel dos Santos Silva, Gianluca Severi, Ute Hamann, Paul Pharoah, Douglas F. Easton, Jenny Chang-Claude, Drakoulis Yannoukakos, Heli Nevanlinna, Xianshu Wang & Fergus J. Couch,
2011, Cancer Research, 71(19), 6240-6249
Type: article
Kevin D. Boyd, Fiona M. Ross, William J. Tapper, Laura Chiecchio, GianPaolo Dagrada, Zoe J. Konn, David Gonzalez, Brian A. Walker, Sarah L. Hockley, Christopher P. Wardell, Walter M. Gregory, J. Anthony Child, Graham H. Jackson, Faith E. Davies & Gareth J. Morgan,
2011, Genes, Chromosomes and Cancer, 50(10), 765-774
DOI: 10.1002/gcc.20899
Type: article
Kevin D. Boyd, Fiona M. Ross, Laura Chiecchio, GianPaolo Dagrada, Zoe J. Konn, William J. Tapper, Brian A. Walker, Christopher P. Wardell, Walter M. Gregory, Alex J. Szubert, Faith E. Davies & Gareth J. Morgan,
2011, Cancer Epidemiology, Biomarkers & Prevention, 20(8), 1703-1707
Type: article
Ioannis Politopoulos, Jane Gibson, William Tapper, Sarah Ennis, Diana Eccles & Andrew Collins,
2011, Journal of Human Genetics, 56(5), 377-382
DOI: 10.1038/jhg.2011.23
Type: article
Ioannis Politopoulos, Jane Gibson, William Tapper, Sarah Ennis, Diana Eccles & Andrew Collins,
2011, European Journal of Human Genetics, 19(2), 194-199
Type: article
William Tapper, Laura Chiecchio, Gian Paolo Dagrada, Zoe J. Konn, David M. Stockley, Alex J. Szubert, Walter M. Gregory, Susan E. Bell, Graham H. Jackson, J. Anthony Child, Gareth J. Morgan & Fiona M. Ross,
2011, Journal of Clinical Oncology, 29(2), e37-e39
Type: article
X.R. Yang, J. Chang-Claude, E.L. Goode, F.J. Couch, H. Nevanlinna, R. L. Milne, M. Gaudet, M. K. Schmidt, A. Broeks, A. Cox, P. A. Fasching, R. Hein, A. B. Spurdle, F. Blows, K. Driver, D. Flesch-Janys, J. Heinz, P. Sinn, A. Vrieling, T. Heikkinen, K. Aittomaki, P. Heikkila, C. Blomqvist, J. Lissowska, B. Peplonska, S. Chanock, J. Figueroa, L. Brinton, P. Hall, K. Czene, K. Humphreys, H. Darabi, J. Liu, L. J. Van 't Veer, F. E. van Leeuwen, I. L. Andrulis, G. Glendon, J. A. Knight, A. M. Mulligan, F. P. O'Malley, N. Weerasooriya, E. M. John, M. W. Beckmann, A. Hartmann, S. B. Weihbrecht, D. L. Wachter, S. M. Jud, C. R. Loehberg, L. Baglietto, D. R. English, G. G. Giles, C. A. McLean, G. Severi, D. Lambrechts, T. Vandorpe, C. Weltens, R. Paridaens, A. Smeets, P. Neven, H. Wildiers, X. Wang, J. E. Olson, V. Cafourek, Z. Fredericksen, M. Kosel, C. Vachon, H. E. Cramp, D. Connley, S. S. Cross, S. P. Balasubramanian, M. W. R. Reed, T. Dork, M. Bremer, A. Meyer, J. H. Karstens, A. Ay, T.-W. Park-Simon, P. Hillemanns, J. I. Arias Perez, P. M. Rodriguez, P. Zamora, J. Benitez, Y.-D. Ko, H.-P. Fischer, U. Hamann, B. Pesch, T. Bruning, C. Justenhoven, H. Brauch, D. M. Eccles, W.J. Tapper, S.M. Gerty, E. J. Sawyer, I. P. Tomlinson, A. Jones, M. Kerin, N. Miller, N. McInerney, H. Anton-Culver, A. Ziogas, C.-Y. Shen, C.-N. Hsiung, P.-E. Wu, S.-L. Yang, J.-C. Yu, S.-T. Chen, G.-C. Hsu, C. A. Haiman, B. E. Henderson, L. Le Marchand, L. N. Kolonel, A. Lindblom, S. Margolin, A. Jakubowska, J. Lubinski, T. Huzarski, T. Byrski, B. Gorski, J. Gronwald, M. J. Hooning, A. Hollestelle, A. M. W. van den Ouweland, A. Jager, M. Kriege, M. M. A. Tilanus-Linthorst, M. Collee, S. Wang-Gohrke, K. Pylkas, A. Jukkola-Vuorinen, K. Mononen, M. Grip, P. Hirvikoski, R. Winqvist, A. Mannermaa, V.-M. Kosma, J. Kauppinen, V. Kataja, P. Auvinen, Y. Soini, R. Sironen, S. E. Bojesen, D. Dynnes Orsted, D. Kaur-Knudsen, H. Flyger, B. G. Nordestgaard, H. Holland, G. Chenevix-Trench, S. Manoukian, M. Barile, P. Radice, S. E. Hankinson, D. J. Hunter, R. Tamimi, S. Sangrajrang, P. Brennan, J. McKay, F. Odefrey, V. Gaborieau, P. Devilee, P. E. A. Huijts, R. Tollenaar, C. Seynaeve, G. S. Dite, C. Apicella, J. L. Hopper, F. Hammet, H. Tsimiklis, L. D. Smith, M. C. Southey, M. K. Humphreys, D. Easton, P. Pharoah, M. E. Sherman & M. Garcia-Closas,
2011, JNCI Journal of the National Cancer Institute, 103(3), 250-263
DOI: 10.1093/jnci/djq526
Type: article
Andrew Collins & William J. Tapper,
2010
Type: bookChapter
Teaching
Dr Tapper is the Module lead for 'Genomic Technologies and Basic Informatics' and 'Genomic Informatics' for the MSc in Genomics. He delivers lectures for several modules, supervises MSc, PhD and iPhD students and marks their research projects.
Dr Tapper contributes to undergraduate teaching of Medicine (BM5) via his role as the Head of Feild for Genetics and as a Personal Academic tutor. He also supervises and marks third year student projects.