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Research project

Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Staff

Lead researchers

Professor Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Professor

Research interests

  • Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
  • Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
  • Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.
Connect with Hans Michael

Email: [email protected]

Research outputs

Involvement of the epidermal growth factor receptor in IL-13 mediated, corticosteroid-resistant airway inflammation
Elizabeth R. Davies, Jeanne Marie Perotin, Joanne Kelly, Ratko Djukanovic, Donna E. Davies & Hans Michael Haitchi, 2020, Clinical & Experimental Allergy, 50(6), 672-686
DOI: 10.1111/cea.13591
Type: article
Airway hyperresponsiveness in offspring from mothers with allergic airway inflammation during pregnancy is muscarinic receptor and ADAM33 dependent
Marieke Wandel, Elizabeth Rhiannon Davies, Joanne Freda Carmichael Kelly, Stephen Holgate, Donna Davies & Hans Haitchi, 2020
DOI: 10.1183/13993003.congress-2020.614
Type: conference
Maternal allergic airway inflammation during pregnancy alters offspring’s airway hyperresponsiveness dependent on muscarinic receptor and adam33 mediated mechanisms
Marieke Wandel, Elizabeth Rhiannon Davies, Joanne Freda Carmichael Kelly, Stephen Holgate, Jeffrey A. Whitsett, Donna Davies & Hans Haitchi, 2019
DOI: 10.1136/thorax-2019-BTSabstracts2019.136
Type: conference
Regulation of Ectodomain shedding of ADAM33 in vitro and in vivo
Elizabeth R. Davies, Laura Denney, Marieke Wandel, Clare M. Lloyd, Donna E. Davies & Hans Michael Haitchi, 2019, Journal of Allergy and Clinical Immunology, 143(6), 2281-2284.e3
DOI: 10.1016/j.jaci.2019.01.026
Type: letterEditorial
Protocol for the Wessex AsThma CoHort of difficult asthma (WATCH)
Adnan Azim, Heena Mistry, Anna Freeman, Clair Barber, Colin Newell, Kerry Gove, Yvette Thirlwall, Matt Harvey, Kimberley Bentley, Deborah Knight, Karen Long, Frances Mitchell, Yueqing Cheng, Judit Varkonyi-Sepp, Wolfgang Grabau, Paddy Dennison, Hans Michael Haitchi, S Hasan Arshad, Ratko Djukanovic, Tom Wilkinson, Peter Howarth & Ramesh J Kurukulaaratchy, 2019, BMC Pulmonary Medicine, 19
DOI: 10.1186/s12890-019-0862-2
Type: article