Research project

Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Lead researchers:

Professor Hans Michael Haitchi
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researchers

Professor Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Professor

Research interests

Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Connect with Hans Michael

Email: [email protected]

Research outputs

ADAM33

Hans Michael Haitchi & Donna E. Davies, 2012

DOI: 10.1016/B978-0-12-382219-2.00257-X

Type: bookChapter

Resistin‐like molecule‐β is induced following bronchoconstriction of asthmatic airways

Christopher L. Grainge, Valdeep Dulay, Jonathan Ward, David Sammut, Elizabeth Davies, Benjamin Green, Laurie C.K. Lau, Laura Cottey, Hans-Michael Haitchi, Donna E. Davies & Peter H. Howarth, 2012, Respirology, 17(7), 1094-1100

DOI: 10.1111/j.1440-1843.2012.02215.x

Type: article

SAM-pointed domain ETS factor mediates epithelial cell-intrinsic innate immune signaling during airway mucous metaplasia

T.R. Korfhagen, J. Kitzmiller, G. Chen, A. Sridharan, H.M. Haitchi, R.S. Hegde, S. Divanovic, C.L. Karp & J.A. Whitsett, 2012, Proceedings of the National Academy of Sciences, 109(41), 16630-16635

DOI: 10.1073/pnas.1208092109

Type: article

Regulation of a disintegrin and metalloprotease-33 expression by transforming growth factor-?

Youwen Yang, James Wicks, Hans Michael Haitchi, Robert M. Powell, Wiparat Manuyakorn, Peter H. Howarth, Stephen T. Holgate & Donna E. Davies, 2012, American Journal of Respiratory Cell and Molecular Biology, 46(5), 633-640

DOI: 10.1165/rcmb.2011-0030OC

Type: article

Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis

Elizabeth R. Davies, Hans Michael Haitchi, Thomas H. Thatcher, Patricia J. Sime, R. Matthew Kottmann, Arasu Ganesan, Graham Packham, Katherine M.A. O'Reilly & Donna E. Davies, 2012, American Journal of Respiratory Cell and Molecular Biology, 46(5), 687-694

DOI: 10.1165/rcmb.2011-0040OC

Type: article