Research project

Dr H M Haitchi ADAM33 gene and environmental interactions in developing lungs and their involvement in the early life origin of asthma

Lead researchers:

Professor Hans Michael Haitchi
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researchers

Professor Hans Michael Haitchi MD, MMed(INT), PhD, PD, MRCP(London), FHEA, PGcert

Professor

Research interests

Study of the asthma susceptibility gene A Disintegrin and Metalloprotease 33 (ADAM33) in early life and adult asthma and other chronic lung diseases.
Development of novel Anti-ADAM33 agents as potential disease modifying asthma therapy.
Multiomic study of the influence of the maternal environment (e.g. allergic asthma, obesity) during pregnancy on ADAM33 and other mediators and the early origin of lung disease in the Maternal Environment in Pregnancy (MEP) cohort.

Connect with Hans Michael

Email: [email protected]

Research outputs

Increased expression of p22phox mediates airway hyperresponsiveness in an experimental model of asthma

Chandran Nagaraj, Hans Michael Haitchi, Akos Heinemann, Peter Howarth, Andrea Olschewski & Leigh M Marsh, 2017, Antioxidants & Redox Signaling, 27(18), 1460-1472

DOI: 10.1089/ars.2016.6863

Type: article

Corticosteroid-resistant neutrophilic airway inflammation and hyperresponsiveness caused by il-13

Elizabeth Davies, Joanne, Freda Carmichael Kelly, J.A. Whitsett, Stephen Holgate, Donna Davies & Hans Haitchi, 2017

DOI: 10.1136/thoraxjnl-2017-210983.91

Type: conference

Soluble adam33 augments the pulmonary immune response promoting allergic airway sensitivity

Joanne, Freda Carmichael Kelly, Elizabeth Davies, Stephen Holgate, X Xu, J.A. Whitsett, Donna Davies & Hans Haitchi, 2017

DOI: 10.1136/thoraxjnl-2017-210983.95

Type: conference

Locked Nucleic Acid gapmers and conjugates induce potent silencing of ADAM33, an asthma-associated metalloprotease with nuclear-localized mRNA

Hannah M Pendergraff, Pranathi Meda Krishnamurthy, Alexandre J. Debacker, Michael Moazami, Vivek K. Sharma, Liisa Niitsoo, Yong Yu, Yen Nee Tan, Hans Michael Haitchi & Jonathan K. Watts, 2017, Molecular Therapy: Nucleic Acid

DOI: 10.1016/j.omtn.2017.06.012

Type: article

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life

Elizabeth R. Davies, Joanne F. Kelly, Peter H. Howarth, David Wilson, Stephen Holgate, Donna E. Davies, Jeffrey A. Whitsett & Hans Michael Haitchi, 2016, JCI Insight, 1(11), 1-16

DOI: 10.1172/jci.insight.87632

Type: article